Targeting negative regulation of p53 by MDM2 and WIP1 as a therapeutic strategy in cutaneous melanoma

被引:0
|
作者
Chiao-En Wu
Arman Esfandiari
Yi-Hsuan Ho
Nan Wang
Ahmed Khairallah Mahdi
Erhan Aptullahoglu
Penny Lovat
John Lunec
机构
[1] Northern Institute for Cancer Research,Division of Hematology
[2] School of Medicine,Oncology, Department of Internal Medicine
[3] Newcastle University,Department of Pathology and Forensic Medicine
[4] Chang Gung Memorial Hospital at Linkou,undefined
[5] Chang Gung University College of Medicine,undefined
[6] Arraygen UK Ltd,undefined
[7] Devonshire Building,undefined
[8] Newcastle University,undefined
[9] College of Medicine,undefined
[10] Al-Nahrain University,undefined
[11] Dermatological Sciences,undefined
[12] Institute of Cellular Medicine,undefined
[13] Newcastle University,undefined
来源
British Journal of Cancer | 2018年 / 118卷
关键词
cutaneous melanoma; p53; MDM2; WIP1; nutlin-3; RG7388; HDM201;
D O I
暂无
中图分类号
学科分类号
摘要
引用
收藏
页码:495 / 508
页数:13
相关论文
共 50 条
  • [1] Targeting negative regulation of p53 by MDM2 and WIP1 as a therapeutic strategy in cutaneous melanoma
    Wu, Chiao-En
    Esfandiari, Arman
    Ho, Yi-Hsuan
    Wang, Nan
    Mahdi, Ahmed Khairallah
    Aptullahoglu, Erhan
    Lovat, Penny
    Lunec, John
    BRITISH JOURNAL OF CANCER, 2018, 118 (04) : 495 - 508
  • [2] The Wip1 phosphatase and Mdm2: Cracking the "Wip" on p53 sta
    Lu, Xiongbin
    Nguyen, Thuy-Ai
    Zhang, Xinna
    Donehower, Lawrence A.
    CELL CYCLE, 2008, 7 (02) : 164 - 168
  • [3] Activating p53 through MDM2 and WIP1 inhibition effectively inhibits tumors in liver adenocarcinoma
    Chen, Chiao-Ping
    Yeh, Chun-Nan
    Pan, Yi-Ru
    Hsiao, Yu-Tien
    Lo, Chih-Hong
    Jhuang, Cai-Jhen
    Wu, Chiao-En
    CANCER RESEARCH, 2022, 82 (12)
  • [4] Negative regulation of p53 functions by Daxx and the involvement of MDM2
    Zhao, LY
    Liu, JL
    Sidhu, GS
    Niu, YX
    Liu, Y
    Wang, RP
    Liao, DQ
    JOURNAL OF BIOLOGICAL CHEMISTRY, 2004, 279 (48) : 50566 - 50579
  • [5] Regulation of p53 stability by Mdm2
    Kubbutat, MHG
    Jones, SN
    Vousden, KH
    NATURE, 1997, 387 (6630) : 299 - 303
  • [6] Regulation of p53 stability by Mdm2
    Michael H. G. Kubbutat
    Stephen N. Jones
    Karen H. Vousden
    Nature, 1997, 387 : 299 - 303
  • [7] Polymorphisms of p53 and its negative regulator MDM2 in human melanoma
    Firoz, E. F.
    Warycha, M.
    Shapiro, R.
    Berman, R.
    Kamino, H.
    Darvishian, F.
    Rolnitzky, L.
    Goldberg, J.
    Osman, I.
    Polsky, D.
    JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2008, 128 : S226 - S226
  • [8] Regulation of p53 by Mdm2: Fate is in the numbers
    Shmueli, A
    Oren, M
    MOLECULAR CELL, 2004, 13 (01) : 4 - 5
  • [9] Regulation of p53 and MDM2 activity by MTBP
    Brady, M
    Vlatkovic, N
    Boyd, MT
    MOLECULAR AND CELLULAR BIOLOGY, 2005, 25 (02) : 545 - 553
  • [10] Critical role for Ser20 of human p53 in the negative regulation of p53 by Mdm2
    Unger, T
    Juven-Gershon, T
    Moallem, E
    Berger, M
    Sionov, RV
    Lozano, G
    Oren, M
    Haupt, Y
    EMBO JOURNAL, 1999, 18 (07): : 1805 - 1814