c-Abl inhibition mitigates diet-induced obesity through improving insulin sensitivity of subcutaneous fat in mice

被引:0
作者
Rong Wu
Jian-guang Sun
Ji-qiu Wang
Binhua Li
Qingsong Liu
Guang Ning
Wanzhu Jin
Zengqiang Yuan
机构
[1] Institute of Biophysics,State Key Laboratory of Brain and Cognitive Sciences
[2] Chinese Academy of Sciences,College of Life Sciences
[3] University of Chinese Academy of Sciences,Sino
[4] University of Chinese Academy of Sciences,Danish Center Neuroscience Program
[5] Ruijin Hospital Affiliated to Shanghai Jiaotong University School of Medicine,High Magnetic Field Laboratory
[6] Chinese Academy of Sciences,undefined
[7] Key Laboratory of Animal Ecology and Conservation Biology,undefined
[8] Institute of Zoology,undefined
[9] Chinese Academy of Sciences,undefined
[10] Center of Alzheimerʼs Disease,undefined
[11] Beijing Institute for Brain Disorders,undefined
来源
Diabetologia | 2017年 / 60卷
关键词
Adiponectin; c-Abl; Insulin resistance; Nilotinib; Obesity;
D O I
暂无
中图分类号
学科分类号
摘要
引用
收藏
页码:900 / 910
页数:10
相关论文
共 156 条
[11]  
Eckel RH(2012)Regulation of neuronal cell death by c-Abl-Hippo/MST2 signaling pathway PLoS One 7 e36562-552
[12]  
Grundy SM(2016)c-Abl-p38α signaling plays an important role in MPTP-induced neuronal death Cell Death Differ 23 542-571
[13]  
Zimmet PZ(2013)Role of ABL family kinases in cancer: from leukaemia to solid tumours Nat Rev Cancer 13 559-1042
[14]  
Kahn SE(2001)Activity of a specific inhibitor of the BCR-ABL tyrosine kinase in the blast crisis of chronic myeloid leukemia and acute lymphoblastic leukemia with the Philadelphia chromosome N Engl J Med 344 1038-652
[15]  
Hull RL(2002)Hematologic and cytogenetic responses to imatinib mesylate in chronic myelogenous leukemia N Engl J Med 346 645-540
[16]  
Utzschneider KM(2002)Complete molecular remission in chronic myelogenous leukemia after imatinib therapy N Engl J Med 347 539-1050
[17]  
Cnop M(2005)Imatinib and regression of type 2 diabetes N Engl J Med 352 1049-3767
[18]  
Landchild MJ(2010)Plasma adiponectin levels are markedly elevated in imatinib-treated chronic myeloid leukemia (CML) patients: a mechanism for improved insulin sensitivity in type 2 diabetic CML patients? J Clin Endocrinol Metab 95 3763-71
[19]  
Vidal J(2008)Imatinib mesylate improves insulin sensitivity and glucose disposal rates in rats fed a high-fat diet Clin Sci (Lond) 114 65-1338
[20]  
Tran TT(2013)Imatinib mesilate-induced phosphatidylinositol 3-kinase signalling and improved survival in insulin-producing cells: role of Src homology 2-containing inositol 5′-phosphatase interaction with c-Abl Diabetologia 56 1327-240