c-Abl inhibition mitigates diet-induced obesity through improving insulin sensitivity of subcutaneous fat in mice

Ng M(2014)Global, regional, and national prevalence of overweight and obesity in children and adults during 1980-2013: a systematic analysis for the Global Burden of Disease Study 2013 Lancet 384 766-781

Fleming T(2012)Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: a systematic analysis for the Global Burden of Disease Study 2010 Lancet 380 2095-2128

Robinson M(2003)Genotype, obesity and cardiovascular disease--has technical and social advancement outstripped evolution? J Intern Med 254 114-125

Lozano R(2001)Insulin signalling and the regulation of glucose and lipid metabolism Nature 414 799-806

Naghavi M(2005)The metabolic syndrome Lancet 365 1415-1428

Foreman K(2006)Mechanisms linking obesity to insulin resistance and type 2 diabetes Nature 444 840-846

Zimmet P(2002)The concurrent accumulation of intra-abdominal and subcutaneous fat explains the association between insulin resistance and plasma leptin concentrations: distinct metabolic effects of two fat compartments Diabetes 51 1005-1015

Thomas CR(2010)Transplantation of adipose tissue and stem cells: role in metabolism and disease Nat Rev Endocrinol 6 195-213

Saltiel AR(2008)Cytoplasmic signalling by the c-Abl tyrosine kinase in normal and cancer cells Biol Cell 100 617-631

Kahn CR(2011)The c-Abl-MST1 signaling pathway mediates oxidative stress-induced neuronal cell death J Neurosci 31 9611-9619

Ng M(2014)Global, regional, and national prevalence of overweight and obesity in children and adults during 1980-2013: a systematic analysis for the Global Burden of Disease Study 2013 Lancet 384 766-781

Fleming T(2012)Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: a systematic analysis for the Global Burden of Disease Study 2010 Lancet 380 2095-2128

Robinson M(2003)Genotype, obesity and cardiovascular disease--has technical and social advancement outstripped evolution? J Intern Med 254 114-125

Lozano R(2001)Insulin signalling and the regulation of glucose and lipid metabolism Nature 414 799-806

Naghavi M(2005)The metabolic syndrome Lancet 365 1415-1428

Foreman K(2006)Mechanisms linking obesity to insulin resistance and type 2 diabetes Nature 444 840-846

Zimmet P(2002)The concurrent accumulation of intra-abdominal and subcutaneous fat explains the association between insulin resistance and plasma leptin concentrations: distinct metabolic effects of two fat compartments Diabetes 51 1005-1015

Thomas CR(2010)Transplantation of adipose tissue and stem cells: role in metabolism and disease Nat Rev Endocrinol 6 195-213

Saltiel AR(2008)Cytoplasmic signalling by the c-Abl tyrosine kinase in normal and cancer cells Biol Cell 100 617-631

Kahn CR(2011)The c-Abl-MST1 signaling pathway mediates oxidative stress-induced neuronal cell death J Neurosci 31 9611-9619