HOX transcription factors are potential therapeutic targets in non-small-cell lung cancer (targeting HOX genes in lung cancer)

被引：0
作者：
L Plowright
K J Harrington
H S Pandha
R Morgan
机构：
[1] Postgraduate Medical School,
[2] Faculty of Health and Medical Sciences,undefined
[3] University of Surrey,undefined
[4] Targeted Therapy Team,undefined
[5] Chester Beatty Laboratories,undefined
[6] The Institute of Cancer Research,undefined
来源：
British Journal of Cancer | 2009年 / 100卷
关键词：
lung cancer; NSCLC; HOX; PBX;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
The HOX genes are a family of homeodomain-containing transcription factors that determine the identity of cells and tissues during embryonic development. They are also known to behave as oncogenes in some haematological malignancies. In this study, we show that the expression of many of the HOX genes is highly elevated in primary non-small-cell lung cancers (NSCLCs) and in the derived cell lines A549 and H23. Furthermore, blocking the activity of HOX proteins by interfering with their binding to the PBX co-factor causes these cells to undergo apoptosis in vitro and reduces the growth of A549 tumours in vivo. These findings suggest that the interaction between HOX and PBX proteins is a potential therapeutic target in NSCLC.
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页码：470 / 475
页数：5
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