Menin orchestrates hepatic glucose and fatty acid uptake via deploying the cellular translocation of SIRT1 and PPARγ

被引：0

作者：

Tingjun Liu

Ranran Li

Lili Sun

Zhongjin Xu

Shengxuan Wang

Jingxuan Zhou

Xuanning Wu

Kerong Shi

机构：

[1] Shandong Agricultural University,Laboratory of Animal Stem Cell and Reprogramming, College of Animal Science and Technology

[2] Key Laboratory of Animal Bioengineering and Disease Prevention of Shandong Province,undefined

来源：

Cell & Bioscience | / 13卷

关键词：

Menin; Hepatocytes; PPARγ; SIRT1; NAFLD; Metabolism homeostatsis;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

Higher Menin facilitates hepatic glucose uptake, but restrains hepatic fatty acid uptake. Conversely, lower Menin has the opposite effect.Menin interacts with PPARγ and/or FoxO1, as well as SIRT1, thereby targeting downstream gene expression.Through its recruitment of various proteins, Menin facilitates their translocations within the nucleus and cytoplasm.Menin serves as a key regulator of hepatic metabolism homeostasis.Menin expression is elevated in both induced fatty hepatocyte model and fatty liver tissues.

引用

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