Visualization of Insulin-Loaded Nanocapsules: In Vitro and in Vivo Studies After Oral Administration to Rats

被引：0
作者：
Huguette Pinto-Alphandary
Malam Aboubakar
Danielle Jaillard
Patrick Couvreur
Christine Vauthier
机构：
[1] Université,UMR CNRS 8612, Laboratoire de Physico
[2] Université Paris-Sud,Chimie, Pharmacotechnie et Biopharmacie, Faculté de Pharmacie
来源：
Pharmaceutical Research | 2003年 / 20卷
关键词：
insulin; nanocapsules; poly(isobutylcyanoacrylate); oral delivery; intestinal tract;
D O I：
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中图分类号：
学科分类号：
摘要：
Purpose. Biodegradable poly(isobutylcyanoacrylate) nanocapsules have been recognized as a promising carrier for oral administration of peptides and proteins. In the present study, we investigate the fate of insulin-loaded nanocapsules by fluorescence and transmission electron microscopy (TEM) after intragastric force-feeding to rats.
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页码：1071 / 1084
页数：13
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