Dyslipidemia in South Asian patients

被引：48

作者：

Enas E.A. ^{[1
]}

Chacko V. ^{[1
]}

Pazhoor S.G. ^{[1
]}

Chennikkara H. ^{[1
]}

Devarapalli H.P. ^{[1
]}

机构：

[1] Coronary Artery Disease in Indians (CADI) Research Foundation, Lisle, IL 60532

来源：

Current Atherosclerosis Reports | 2007年 / 9卷 / 5期

关键词：

Coronary Artery Disease; Rosuvastatin; Ezetimibe; Coronary Artery Disease Risk; Premature Coronary Artery Disease;

D O I：

10.1007/s11883-007-0047-y

中图分类号：

学科分类号：

摘要：

South Asians around the globe have the highest rates of coronary artery disease (CAD). These rates are 50% to 300% higher than other' populations, with a higher risk at younger ages. These high rates of CAD are accompanied by low or similar rates of major traditional risk factors. The prevalence of diabetes is three to six times higher among South Asians than Europeans, Americans, and other Asians but does not explain the "South Asian Paradox." A genetic predisposition to CAD, mediated by high levels of lipoprotein(a), markedly magnifies the adverse effects of traditional risk factors related to lifestyle and best explains the South Asian Paradox. Although the major modifiole risk factors do not fully explain the excess burdeo of CAD, they are doubly important and remain the foundation of preventive and therapeutic strategies5n this population. A more aggressive approach to preventive therapy, especially dyslipidemia, at an earlier age and at a lower threshold is clearly warranted. Copyright © 2007 by Current Medicine Group LLC.

引用

页码：367 / 374

页数：7

共 47 条

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