p53 Gene therapy for lung cancer.

被引：20
作者：
Swisher S.G. [1 ]
Roth J.A. [1 ]
机构：
[1] Department of Thoracic and Cardiovascular Surgery, The University of Texas M.D. Anderson Cancer Center, 1515 Holcombe Boulevard, Box 445, Houston
来源：
Current Oncology Reports | 2002年 / 4卷 / 4期
关键词：
Lung Cancer; Locoregional Control; Proc ASCO; Metastatic NSCLC; Intratumoral Delivery;
D O I：
10.1007/s11912-002-0009-z
中图分类号：
学科分类号：
摘要：
The gene transfer of the tumor suppressor p53 gene has been shown to induce tumor regression in preclinical models. Recent phase I and II studies have been completed in lung cancer with adenoviral-mediated transfer of wild-type p53 (Ad-p53) either alone or in combination with chemotherapy or radiotherapy. These studies have demonstrated acceptable toxicity and evidence of tumor regression with intratumoral delivery of Ad-p53. The predominant clinical effect appears to be locoregional in the area of intratumoral delivery. Further phase III studies are needed to determine if Ad-p53 will play a therapeutic role as a novel agent to treat non-small-cell lung cancer.
引用
收藏
页码：334 / 340
页数：6
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