Secondary prevention of heart disease in women: Gaps in care/gaps in knowledge—where do we need to focus our attention

被引:0
作者
Lau E. [1 ]
Foody J.A.M. [2 ,3 ]
机构
[1] Department of Medicine, Brigham and Women’s Hospital, 75 Francis Street, PB-136, Boston, 02115, MA
[2] Harvard Medical School, Boston, MA
[3] Division of Cardiovascular Medicine, Brigham and Women’s Hospital, 75 Francis Street, PB-136, Boston, 02115, MA
关键词
Cardiovascular disease; Coronary artery disease; Secondary prevention; Women;
D O I
10.1007/s12170-015-0452-7
中图分类号
学科分类号
摘要
Cardiovascular disease (CVD) is the leading cause of death in women in the USA, and yet, CVD is consistently underestimated and undertreated in women. Awareness of this gender gap is growing, but still persists. Women with existing CVD are a particularly vulnerable and neglected population. Better understanding of the secondary prevention of CVD is sorely needed. Women are underrepresented in all CVD trials and sex-specific research is lacking. Consequently, the present guidelines for the secondary prevention of CVD in women are largely derived from studies performed in men. Albeit imperfect, these guidelines are less frequently applied to female patients. CVD outcomes are consistently worse in women than men, highlighting the need to address this gender disparity. We review the current guidelines and data on the secondary prevention of CVD in women and outline areas in need of further investigation and intervention. © 2015, Springer Science+Business Media New York.
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页码:1 / 10
页数:9
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  • [1] Mosca L., Barrett-Connor E., Wenger N.K., Sex/gender differences in cardiovascular disease prevention: what a difference a decade makes, Circulation, 124, 19, pp. 2145-2154, (2011)
  • [2] Vaccarino V., Parsons L., Every N.R., Barron H.V., Krumholz H.M., Sex-based differences in early mortality after myocardial infarction. National Registry of Myocardial Infarction 2 Participants, N Engl J Med, 341, 4, pp. 217-225, (1999)
  • [3] Mulcahy R., Hickey N., Maurer B., Coronary heart disease in women. Study of risk factors in 100 patients less than 60 years of age, Circulation, 36, 4, pp. 577-586, (1967)
  • [4] Gulati M., Shaw L.J., Bairey Merz C.N., Myocardial ischemia in women: lessons from the NHLBI WISE study, Clin Cardiol, 35, 3, pp. 141-148, (2012)
  • [5] Clayton J.A., Collins F.S., Policy: NIH to balance sex in cell and animal studies, Nature, 509, 7500, pp. 282-283, (2014)
  • [6] Stone N.J., Robinson J.G., Lichtenstein A.H., Bairey Merz C.N., Blum C.B., Eckel R.H., Et al., 2013 ACC/AHA guideline on the treatment of blood cholesterol to reduce atherosclerotic cardiovascular risk in adults: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines, Circulation, 129, 25 Suppl 2, pp. S1-S45, (2014)
  • [7] Mosca L., Benjamin E.J., Berra K., Bezanson J.L., Dolor R.J., Lloyd-Jones D.M., Et al., Effectiveness-based guidelines for the prevention of cardiovascular disease in women—2011 update: a guideline from the American Heart Association, Circulation, 123, 11, pp. 1243-1262, (2011)
  • [8] Kritchevsky D., Dietary protein, cholesterol and atherosclerosis: a review of the early history, J Nutr, 125, 3 Suppl, pp. 589s-593, (1995)
  • [9] Bowen D.J., Henderson M.M., Iverson D., Burrows E., Henry H., Foreyt J., Reducing dietary fat: understanding the success of the women’s health trial, Cancer Prev Int, 1, 1, pp. 21-30, (1994)
  • [10] Krummel D.A., Koffman D.M., Bronner Y., Davis J., Greenlund K., Tessaro I., Et al., Cardiovascular health interventions in women: what works?, J Womens Health Gend Based Med, 10, 2, pp. 117-136, (2001)