A systematic review of nano formulation of natural products for the treatment of inflammatory bowel disease: drug delivery and pharmacological targets

被引：43

作者：

Taghipour, Yasamin Davatgaran ^{[1
,2
,3
]}

Bahramsoltani, Roodabeh ^{[2
,4
]}

Marques, Andre M. ^{[5
]}

Naseri, Rozita ^{[6
]}

Rahimi, Roja ^{[4
]}

Haratipour, Pouya ^{[7
,8
]}

Panah, Amin Iran ^{[9
]}

Farzaei, Mohammad Hosein ^{[10
,11
]}

Abdollahi, Mohammad ^{[12
,13
]}

机构：

[1] Tabriz Univ Med Sci, Sch Adv Med Sci, Dept Med Nanotechnol, Tabriz, Iran

[2] USERN, PhytoPharmacol Interest Grp PPIG, Tehran, Iran

[3] Tabriz Univ Med Sci, Student Res Comm, Tabriz, Iran

[4] Univ Tehran Med Sci, Sch Persian Med, Dept Pharm Persian Med, Tehran, Iran

[5] Oswaldo Cruz Fdn FIOCRUZ, Inst Technol Pharmaceut Farmanguinhos, Rio De Janeiro, RJ, Brazil

[6] Kermanshah Univ Med Sci, Dept Internal Med, Fac Med, Kermanshah, Iran

[7] Sharif Univ Technol, Dept Chem, Tehran, Iran

[8] USERN, PhytoPharmacol Interest Grp PPIG, Los Angeles, CA USA

[9] Kermanshah Univ Med Sci, Fac Pharm, Kermanshah, Iran

[10] Kermanshah Univ Med Sci, Pharmaceut Sci Res Ctr, Kermanshah, Iran

[11] Kermanshah Univ Med Sci, Med Biol Res Ctr, Kermanshah, Iran

[12] Univ Tehran Med Sci, Toxicol & Dis Grp, Inst Pharmaceut Sci TIPS, Tehran, Iran

[13] Univ Tehran Med Sci, Dept Pharmacol & Toxicol, Fac Pharm, Tehran, Iran

来源：

DARU-JOURNAL OF PHARMACEUTICAL SCIENCES | 2018年 / 26卷 / 02期

关键词：

Inflammatory bowel disease; Natural nanoformulation; Stimuli responsive nanoparticles; Crohn's disease; Ulcerative colitis; ULCERATIVE-COLITIS; LOADED NANOPARTICLES; OXIDATIVE STRESS; EMBELIN; COLON; GINGER; MICE; MICROPARTICLES; NANOCARRIERS; PREVENTION;

D O I：

10.1007/s40199-018-0222-4

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Inflammatory bowel diseases (IBD), which is classified into Crohn's disease and ulcerative colitis, are among chronic gastrointestinal diseases with unknown pathogenesis. Diverse strategies have been applied for the treatment of this chronic disease. However, selective and site-specific routes of drug delivery to the inflamed location of the colon remain of high importance. Consequently, the application and effects of natural products in the form of nanoformulation and stimuli responsive nanoparticles as a novel strategy for the treatment of IBD are discussed in this review article. This approach may potentially overcome some complications that are associated with conventional means of colon drug delivery. Meanwhile, in vitro and in vivo studies pave the way for understanding of the mechanism that lies behind this chronic relapsing disease and potentially more effective treatment.

引用

页码：229 / 239

页数：11

共 66 条

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