Solubility and thermodynamic study of mesalazine in propylene glycol + 2-propanol mixtures

被引：0
作者：
Kader Poturcu
Aynaz Zarghampour
Elaheh Rahimpour
Salar Hemmati
Hongkun Zhao
Abolghasem Jouyban
机构：
[1] Tabriz University of Medical Sciences,Pharmaceutical Analysis Research Center, Faculty of Pharmacy
[2] Suleyman Demirel University,Department of Chemistry, Arts and Science faculty
[3] Tabriz University of Medical Sciences,Student Research Committee, Faculty of Pharmacy
[4] Tabriz University of Medical Sciences,Infectious and Tropical Diseases Research Center
[5] Tabriz University of Medical Sciences,Drug Applied Research Center
[6] YangZhou University,College of Chemistry and Chemical Engineering
[7] Near East University,Faculty of Pharmacy
来源：
Brazilian Journal of Chemical Engineering | 2023年 / 40卷
关键词：
Mesalazine; Solubility; Cosolvency system; Dissolution thermodynamics;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
In the current study, the solubility of mesalazine in the binary mixtures of propylene glycol (PG) + 2-propanol was determined using a shake flask method followed by UV-Vis spectroscopy method. The results showed that the maximum solubility was obtained in neat PG (xm = 4.57 × 10− 4) at 313.2 K and the minimum solubility in the neat 2-propanol (xm = 6.32 × 10− 5) at 293.2 K. In the next step, all data were fitted/back-calculated to several mathematical cosolvency models. Deviations of back-calculated data from experimental values (< 4.0%) show the applicability of the models for the prediction of solubility of meselazine in binary mixtures selected. For saturated systems, density data were also determined and fitted to the adopted form of the Jouyban-Acree model (back-calculated MRD% values were within 0.2%). Furthermore, the thermodynamic behavior of mesalazine in the PG + 2-propanol mixtures was investigated using the Gibbs energy, enthalpy, and entropy calculations at Thm.
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页码：1227 / 1238
页数：11
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