The influence of dose and N-acetyltransferase-2 (NAT2) genotype and phenotype on the pharmacokinetics and pharmacodynamics of isoniazid

被引:0
作者
P. R. Donald
D. P. Parkin
H. I. Seifart
H. S. Schaaf
P. D. van Helden
C. J. Werely
F. A. Sirgel
A. Venter
J. S. Maritz
机构
[1] Stellenbosch University,Paediatrics and Child Health, Faculty of Health Sciences
[2] Stellenbosch University,Department of Pharmacology, Faculty of Health Sciences
[3] Stellenbosch University,Department of Biology and Human Genetics, and the MRC Centre for Molecular and Cellular Biology, DST/NRF Centre of Excellence for Biomedical TB Research, Faculty of Health Sciences
[4] Biostatistics Unit of the South African Medical Research Council,undefined
来源
European Journal of Clinical Pharmacology | 2007年 / 63卷
关键词
Isoniazid; Early bactericidal activity; -acetyltransferase-2; Pharmacokinetics; Pharmacodynamics;
D O I
暂无
中图分类号
学科分类号
摘要
引用
收藏
页码:633 / 639
页数:6
相关论文
共 50 条
  • [31] The Pharmacogenetics of NAT2 Enzyme Maturation in Perinatally HIV Exposed Infants Receiving Isoniazid
    Zhu, Rui
    Kiser, Jennifer J.
    Seifart, Heiner I.
    Werely, Cedric J.
    Mitchell, Charles D.
    D'Argenio, David Z.
    Fletcher, Courtney V.
    JOURNAL OF CLINICAL PHARMACOLOGY, 2012, 52 (04) : 511 - 519
  • [32] Effect of Genetic Variation of NAT2 on Isoniazid and SLCO1B1 and CES2 on Rifampin Pharmacokinetics in Ghanaian Children with Tuberculosis
    Dompreh, Albert
    Tang, Xiaoli
    Zhou, Jianlin
    Yang, Hongmei
    Topletz, Ariel
    Ahwireng, Eugene Adu
    Antwi, Sampson
    Enimil, Antony
    Langaee, Taimour
    Peloquin, Charles A.
    Court, Michael H.
    Kwara, Awewura
    ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2018, 62 (03)
  • [33] Slow N-acetyltransferase 2 genotype affects the incidence of isoniazid and rifampicin-induced hepatotoxicity
    Ohno, M
    Yamaguchi, I
    Yamamoto, I
    Fukuda, T
    Yokota, S
    Maekura, R
    Ito, M
    Yamamoto, Y
    Ogura, T
    Maeda, K
    Komuta, K
    Igarashi, T
    Azuma, J
    INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE, 2000, 4 (03) : 256 - 261
  • [34] N-acetyltransferase 2 (NAT2) genotype as a risk factor for development of drug-induced liver injury relating to antituberculosis drug treatment in a mixed-ethnicity patient group
    Ching-Soon Ng
    Abul Hasnat
    Abdullah Al Maruf
    Maizbha Uddin Ahmed
    Munir Pirmohamed
    Christopher P. Day
    Guruprasad P. Aithal
    Ann K. Daly
    European Journal of Clinical Pharmacology, 2014, 70 : 1079 - 1086
  • [35] N-acetyltransferase 2 (NAT2) genotype as a risk factor for development of drug-induced liver injury relating to antituberculosis drug treatment in a mixed-ethnicity patient group
    Ng, Ching-Soon
    Hasnat, Abul
    Al Maruf, Abdullah
    Ahmed, Maizbha Uddin
    Pirmohamed, Munir
    Day, Christopher P.
    Aithal, Guruprasad P.
    Daly, Ann K.
    EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY, 2014, 70 (09) : 1079 - 1086
  • [36] Arylamine N-acetyltransferase 2 genotype-dependent N-acetylation of isoniazid in cryopreserved human hepatocytes
    Mark A.Doll
    Raúl A.Salazar-González
    Srineil Bodduluri
    David W.Hein
    ActaPharmaceuticaSinicaB, 2017, 7 (04) : 517 - 522
  • [37] Effects of the CYP2C19 genotype and cigarette smoking on the single oral dose pharmacokinetics and pharmacodynamics of estazolam
    Aoshima, T
    Fukasawa, T
    Otsuji, Y
    Okuyama, N
    Gerstenberg, G
    Miura, M
    Ohkubo, T
    Sugawara, K
    Otani, K
    PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY, 2003, 27 (03) : 535 - 538
  • [38] A Rapid Pharmacogenomic Assay to Detect NAT2 Polymorphisms and Guide Isoniazid Dosing for Tuberculosis Treatment
    Verma, Renu
    Patil, Sunita
    Zhang, Nan
    Moreira, Flora M. F.
    Vitorio, Marize T.
    Santos, Andrea da S.
    Wallace, Ellen
    Gnanashanmugam, Devasena
    Persing, David H.
    Savic, Rada M.
    Croda, Julio
    Andrews, Jason R.
    AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2021, 204 (11) : 1317 - 1326
  • [39] Study of NAT2 Gene Polymorphisms in an Indian PopulationAssociation with Plasma Isoniazid Concentration in a Cohort of Tuberculosis Patients
    Neera Singh
    Sudhisha Dubey
    Saravanan Chinnaraj
    Anil Golani
    Anurupa Maitra
    Molecular Diagnosis & Therapy, 2009, 13 : 49 - 58
  • [40] Genetic variants of N-acetyltransferases 1 and 2 (NAT1 and NAT2) in cynomolgus and rhesus macaques
    Uno, Yasuhiro
    Murayama, Norie
    Yamazaki, Hiroshi
    BIOCHEMICAL PHARMACOLOGY, 2020, 177