High EpCAM expression is linked to proliferation and lauren classification in gastric cancer

被引：29

作者：

Kroepil F. ^{[1
]}

Dulian A. ^{[1
]}

Vallböhmer D. ^{[1
]}

Geddert H. ^{[4
]}

Krieg A. ^{[1
]}

Vay C. ^{[1
]}

Topp S.A. ^{[1
]}

Schulte Am Esch J. ^{[1
]}

Baldus S.E. ^{[2
]}

Gires O. ^{[3
]}

Knoefel W.T. ^{[1
]}

Stoecklein N.H. ^{[1
]}

机构：

[1] Department of Surgery (A), Heinrich-Heine-University, University Hospital Duesseldorf, 40225, Düsseldorf

[2] Department of Pathology, Heinrich-Heine-University, University Hospital Duesseldorf, 40225, Düsseldorf

[3] Department of Otorhinolaryngology, Head and Neck Surgery, Grosshadern Medical Center, Ludwig-Maximilians-University of Munich, Munich

[4] Institute of Pathology, St. Vincent's Hospital, Karlsruhe

来源：

BMC Research Notes | / 6卷 / 1期

关键词：

EpCAM expression; Gastric cancer; Ki; 67; Laurén-classification; Overall survival;

D O I：

10.1186/1756-0500-6-253

中图分类号：

学科分类号：

摘要：

Background: The association of EpCAM expression with the progression of gastric cancer remains unclear. Here, we investigated the expression of EpCAM in gastric cancer subtypes and correlated the data to tumor cell proliferation and clinicopathologic factors. Methods. The intratumoral expression of EpCAM was assessed in 163 primary gastric cancers (61 diffuse-, 62 intestinal-, 32 mixed-type and 8 unclassified tumors) by immunohistochemistry, using the monoclonal antibody Ber-EP4. Intensity of staining was classified according the HercepTest-score using a standardized scoring system. Ki-67 was used to examine the proliferation in tumor tissue. Results: Strong EpCAM expression was observed in 77% of the tumors and in 85% of the corresponding lymph nodes. Of the primary tumors, 58% (n=74) presented a homogeneous intratumoral EpCAM expression while 42% were characterised by a heterogenous expression pattern. Tumors with high EpCAM expression at the invasive front were associated with significantly (p=0.03) higher proportion of lymph node metastases and lower median overall survival (p=0.001). Diffuse type tumors presented a significantly higher EpCAM expression at the invasion front compared with the tumor centre (p=0.036). Multivariate survival analysis identified high EpCAM expression at the invasive front as an independent prognostic factor.We observed a significant (p=0.001) correlation between high EpCAM expression and higher tumor cell proliferation. Conclusion: High EpCAM expression associates with proliferation and progression of gastric cancer, especially in the diffuse type. Considering the discontenting results of the current adjuvant concepts for gastric cancer patients, EpCAM might be target in the adjuvant therapy of this malignant disease. © 2013 Kroepil et al.; licensee BioMed Central Ltd.

引用

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