Collective cell migration of epithelial and mesenchymal cells

被引：0
作者：
Eric Theveneau
Roberto Mayor
机构：
[1] University College London,Department of Cell and Developmental Biology
来源：
Cellular and Molecular Life Sciences | 2013年 / 70卷
关键词：
Collective cell migration; Epithelium-to-mesenchyme transition; Contact-inhibition of locomotion; Chemotaxis; Mechanosensing; Mesoderm; Neural crest cells; Cancer;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Directional cell migration is required for proper embryogenesis, immunity, and healing, and its underpinning regulatory mechanisms are often hijacked during diseases such as chronic inflammations and cancer metastasis. Studies on migratory epithelial tissues have revealed that cells can move as a collective group with shared responsibilities. First thought to be restricted to proper epithelial cell types able to maintain stable cell–cell junctions, the field of collective cell migration is now widening to include cooperative behavior of mesenchymal cells. In this review, we give an overview of the mechanisms driving collective cell migration in epithelial tissues and discuss how mesenchymal cells can cooperate to behave as a collective in the absence of bona fide cell–cell adhesions.
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页码：3481 / 3492
页数：11
相关论文
共 599 条
[1]  
Theveneau E(2011)Can mesenchymal cells undergo collective cell migration? The case of the neural crest Cell Adh Migr 5 490-498
[2]  
Mayor R(2009)Collective cell migration Annu Rev Cell Dev Biol 25 407-429
[3]  
Rorth P(2009)Collective cell migration in morphogenesis, regeneration and cancer Nat Rev Mol Cell Biol 10 445-457
[4]  
Friedl P(2012)Neural crest delamination and migration: from epithelium-to-mesenchyme transition to collective cell migration Dev Biol 366 34-54
[5]  
Gilmour D(2011)Complement fragment C3a controls mutual cell attraction during collective cell migration Dev Cell 21 1026-1037
[6]  
Theveneau E(2010)Collective chemotaxis requires contact-dependent cell polarity Dev Cell 19 39-53
[7]  
Mayor R(2010)EphB signaling directs peripheral nerve regeneration through Sox2-dependent Schwann cell sorting Cell 143 145-155
[8]  
Carmona-Fontaine C(2009)Epithelial-mesenchymal transitions in development and disease Cell 139 871-890
[9]  
Theveneau E(2010)Diversity in the molecular and cellular strategies of epithelium-to-mesenchyme transitions: insights from the neural crest Cell Adh Migr 4 458-482
[10]  
Tzekou A(2006)Complex networks orchestrate epithelial-mesenchymal transitions Nat Rev Mol Cell Biol 7 131-142
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