The role of post-translational modifications in hearing and deafness

被引：0
作者：
Susana Mateo Sánchez
Stephen D. Freeman
Laurence Delacroix
Brigitte Malgrange
机构：
[1] University of Liège,Developmental Neurobiology Unit, GIGA
[2] Quartier Hôpital (CHU),Neurosciences
来源：
Cellular and Molecular Life Sciences | 2016年 / 73卷
关键词：
Inner ear; Cochlea; Post-translational modifications; Development; Ototoxicity;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Post-translational modifications (PTMs) are key molecular events that modify proteins after their synthesis and modulate their ultimate functional properties by affecting their stability, localisation, interaction potential or activity. These chemical changes expand the size of the proteome adding diversity to the molecular pathways governing the biological outcome of cells. PTMs are, thus, crucial in regulating a variety of cellular processes such as apoptosis, proliferation and differentiation and have been shown to be instrumental during embryonic development. In addition, alterations in protein PTMs have been implicated in the pathogenesis of many human diseases, including deafness. In this review, we summarize the recent progress made in understanding the roles of PTMs during cochlear development, with particular emphasis on the enzymes driving protein phosphorylation, acetylation, methylation, glycosylation, ubiquitination and SUMOylation. We also discuss how these enzymes may contribute to hearing impairment and deafness.
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页码：3521 / 3533
页数：12
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