pH-responsive polymeric micelles with tunable aggregation-induced emission and controllable drug release

被引：0
|
作者：
Yu Dai
Dengjin Wu
Shijun Lin
Xin Ma
Xiaojin Zhang
Fan Xia
机构：
[1] China University of Geosciences,Engineering Research Center of Nano
来源：
Journal of Nanoparticle Research | 2019年 / 21卷
关键词：
pH-responsive polymeric micelles; Hydrogen-bonding interaction; Aggregation-induced emission; Drug release; Self-assembly; Biomaterials; Nanomedicine;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Stimuli-responsive polymeric micelles as a drug delivery vehicle have made important contributions to the development of controllable drug release. Here we develop pH-responsive polymeric micelles with tunable aggregation-induced emission and controllable drug release. Polymeric micelles in nano-sized spherical shape (about 140 nm) were mediated via hydrogen-bonding interaction between phenol groups of 4,4′-(1,2-diphenylethene-1,2-diyl)diphenol (TPE-2OH) and amine groups of poly(ethylene glycol)-block-linear polyethylenimine-block-poly(ε-caprolactone) (PEG-PEI-PCL). The results show that polymeric micelles are pH-responsive with turn-on fluorescence and sustained drug release inside cells, which has hope in simultaneously achieving cell imaging and cancer therapy.
引用
收藏
相关论文
共 50 条
  • [1] pH-responsive polymeric micelles with tunable aggregation-induced emission and controllable drug release
    Dai, Yu
    Wu, Dengjin
    Lin, Shijun
    Ma, Xin
    Zhang, Xiaojin
    Xia, Fan
    JOURNAL OF NANOPARTICLE RESEARCH, 2019, 21 (01)
  • [2] Degradable pH-responsive polymer prodrug micelles with aggregation-induced emission for cellular imaging and cancer therapy
    Kalva, Nagendra
    Uthaman, Saji
    Lee, Soo Jeong
    Lim, Yu Jeong
    Augustine, Rimesh
    Huh, Kang Moo
    Park, In-Kyu
    Kim, Il
    REACTIVE & FUNCTIONAL POLYMERS, 2021, 166
  • [3] Synthesis and Characterization of pH-responsive Material with Aggregation-induced Emission Property
    Wang J.-H.
    Zeng X.-X.
    Wu Y.
    Lyu X.-C.
    Ren X.-K.
    Yu Z.-Q.
    Ren, Xiang-Kui (renxiangkui@tju.edu.cn), 2021, Editorial Office of Chinese Optics (42): : 311 - 318
  • [4] Redox and pH Dual-Responsive Polymeric Micelles with Aggregation-Induced Emission Feature for Cellular Imaging and Chemotherapy
    Zhuang, Weihua
    Xu, Yangyang
    Li, Gaocan
    Hu, Jun
    Ma, Boxuan
    Yu, Tao
    Su, Xin
    Wang, Yunbing
    ACS APPLIED MATERIALS & INTERFACES, 2018, 10 (22) : 18489 - 18498
  • [5] pH-Responsive supramolecular vesicles for imaging-guided drug delivery: Harnessing aggregation-induced emission
    Wang, Xin-Rui
    Lin, Wei-Xiu
    Lu, Yi-Long
    Kuck, Dietmar
    Xu, Wen-Rong
    ROYAL SOCIETY OPEN SCIENCE, 2024, 11 (09):
  • [6] Mesoscale Simulations of pH-Responsive Amphiphilic Polymeric Micelles for Oral Drug Delivery
    Wu, Zhimin
    Duan, Manzhen
    Xiong, Di
    Zhang, Can Yang
    PHARMACEUTICS, 2019, 11 (12)
  • [7] Tunable Aggregation-Induced Emission of Imidazole Hydrazones by pH and Anions
    Tian, Dongjie
    Zheng, Xin
    Li, Xiaochuan
    Liu, Xiaojing
    Zhao, Jinhu
    Wang, Jianji
    CHEMISTRY-A EUROPEAN JOURNAL, 2019, 25 (72) : 16519 - 16522
  • [8] Fluorescent Polymeric Micelles with Aggregation-Induced Emission Properties for Monitoring the Encapsulation of Doxorubicin
    Chen, Jen-Ing
    Wu, Wen-Chung
    MACROMOLECULAR BIOSCIENCE, 2013, 13 (05) : 623 - 632
  • [9] Drug release profiles of Atenolol and Benidipine from pH-responsive polymeric hydrogel matrix
    Sinem Demir
    Nejla Cini
    Ayşegül Gölcü
    Chemical Papers, 2023, 77 : 4519 - 4529
  • [10] Smart pH-responsive polymeric micelles for programmed oral delivery of insulin
    Hu, Wen Yao
    Wu, Zhi Min
    Yang, Qian Qian
    Liu, Yue Jin
    Li, Juan
    Zhang, Can Yang
    COLLOIDS AND SURFACES B-BIOINTERFACES, 2019, 183
12345