Vitamin K deficiency in diarrhoea

被引：3
作者：
Kumar R. [2 ]
Marwaha N. [2 ]
Marwaha R.K. [1 ,3 ]
Garewal G. [1 ]
机构：
[1] Department of Haematology, Postgrad. Inst. Med. Educ. and Res., Chandigarh
[2] Div. of Pediat. Hematology-Oncology, Advanced Pediatric Centre, Chandigarh
[3] Div. of Pediat. Hematology-Oncology, Advanced Centre, PGIMER
来源：
The Indian Journal of Pediatrics | 2001年 / 68卷 / 3期
关键词：
Acute diarrhoea; Infantile diarrhoea; Intractable diarrhoea; Prothrombin; Protracted diarrhoea; Vitamin K deficiency;
D O I：
10.1007/BF02723197
中图分类号：
学科分类号：
摘要：
The study was undertaken to determine the frequency of occurrence of vitamin K deficiency in infants with diarrhoeal illness. Infants were categorized into four groups as follows: A(acute diarrhoea), B(protracted diarrhoea) C(intractable diarrhoea) and D(healthy controls). Screening coagulation tests, PT and PTTK alongwith estimation of functional activity and total antigenic levels of prothrombin were performed. The ratio of functional to total prothrombin was calculated. PT was prolonged in 30% (24/75) of all infants with diarrhoea as compared to controls where the abnormality was observed in 11.1% infants (2/18). The ratio of functional to total prothrombin was significantly lower in infants with diarrhoea, the mean ± SD values being 0.65±0.41 vs 1.1±0.26. This difference was statistically highly significant (p<0.001). Low ratio was observed in 57.3% (43/75) infants with diarrhoea. Thus functional to total prothrombin ratio identified approximately twice as many diarrhoeal infants with vitamin K deficiency as compared to PT alone. There was no significant correlation with breast feeding as the only mode of diet, or the prior administration of antibiotics in infants with diarrhoea. The inherent malabsorptive state in diarrhoea may be a major contributory factor. [Indian J Pediatr 2001; 68 (3) : 235-238].
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页码：235 / 238
页数：3
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