Assessment of immunization procedures for foot-and-mouth disease in large-scale pig farms in China based on actual data and dynamics

被引:3
作者
Ren, Huarong [1 ,2 ,3 ]
Jin, Zhen [1 ,2 ]
Pei, Xin [4 ]
Li, Mingtao [4 ]
Wang, Youming [5 ]
Zhang, Juan [1 ,2 ]
机构
[1] Shanxi Univ, Complex Syst Res Ctr, Taiyuan 030006, Shanxi, Peoples R China
[2] Shanxi Key Lab Math Tech & Big Data Anal Dis Contr, Taiyuan 030006, Shanxi, Peoples R China
[3] Shanxi Univ, Sch Math Sci, Taiyuan 030006, Shanxi, Peoples R China
[4] Taiyuan Univ Technol, Coll Math, Taiyuan 030024, Shanxi, Peoples R China
[5] China Anim Hlth & Epidemiol Ctr, Lab Anim Epidemiol Surveillance, Qingdao 266032, Shandong, Peoples R China
来源
ANIMAL DISEASES | 2022年 / 2卷 / 01期
关键词
Pig farm; Foot-and-mouth disease; Individual-based state probability model; Immunization procedure; Infection probability; Individual-based control reproduction number; VACCINATION; OUTBREAK; VIRUS; PERSISTENCE; RESPONSES; IMPACTS;
D O I
10.1186/s44149-021-00035-3
中图分类号
S85 [动物医学(兽医学)];
学科分类号
0906 ;
摘要
Foot-and-mouth disease (FMD) is an acute, highly infectious and pathogenic animal disease. In recent years, with the rapid development of the swine breeding industry in China, pig farms have shown a trend of larger-scale development. Large-scale pig farms employ standardized management, a high level of automation, and a strict system. However, these farms have a large trading volume, and increased transmission intensity of FMD is noted inside the farm. At present, the main control measure against FMD is pig vaccination. However, a standard for immunization procedures is not available, and currently adopted immunization procedures have not been effectively and systematically evaluated. Taking a typical large-scale pig farm in China as the research subject and considering the breeding pattern, piggery structure, age structure and immunization procedures, an individual-based state probability model is established to evaluate the effectiveness of the immune procedure. Based on numerical simulation, it is concluded that the optimal immunization program involves primary immunization at 40 days of age and secondary immunization at 80 days of age for commercial pigs. Breeding boars and breeding sows are immunized 4 times a year, and reserve pigs are immunized at 169 and 259 days of age. According to the theoretical analysis, the average control reproduction number of individuals under the optimal immunization procedure in the farm is 0.4927. In the absence of immunization, the average is 1.7498, indicating that the epidemic cannot be controlled without immunization procedures.
引用
收藏
页数:16
相关论文
共 38 条
  • [1] The pathogenesis and diagnosis of foot-and-mouth disease
    Alexandersen, S
    Zhang, Z
    Donaldson, AI
    Garland, AJM
    [J]. JOURNAL OF COMPARATIVE PATHOLOGY, 2003, 129 (01) : 1 - 36
  • [2] Aspects of the persistence of foot-and-mouth disease virus in animals - the carrier problem
    Alexandersen, S
    Zhang, ZD
    Donaldson, AI
    [J]. MICROBES AND INFECTION, 2002, 4 (10) : 1099 - 1110
  • [3] Evolution and molecular epidemiology of foot-and-mouth disease virus in China
    Bai XingWen
    Li PingHua
    Bao HuiFang
    Liu ZaiXin
    Li Dong
    Lu ZengJun
    Cao YiMei
    Shang YouJun
    Shao JunJun
    Chang HuiYun
    Luo JianXun
    Liu XiangTao
    [J]. CHINESE SCIENCE BULLETIN, 2011, 56 (21): : 2191 - 2201
  • [4] Further studies on the early protective responses of pigs following immunisation with high potency foot and mouth disease vaccine
    Barnett, PV
    Cox, SJ
    Aggarwal, N
    Gerber, H
    McCullough, KC
    [J]. VACCINE, 2002, 20 (25-26) : 3197 - 3208
  • [5] Rescue of Foot-and-Mouth Disease Viruses That Are Pathogenic for Cattle from Preserved Viral RNA Samples
    Belsham, Graham J.
    Jamal, Syed M.
    Tjornehoj, Kirsten
    Botner, Anette
    [J]. PLOS ONE, 2011, 6 (01):
  • [6] Epidemic and economic impacts of delayed detection of foot-and-mouth disease: a case study of a simulated outbreak in California
    Carpenter, Tim E.
    O'Brien, Joshua M.
    Hagerman, Amy D.
    McCarl, Bruce A.
    [J]. JOURNAL OF VETERINARY DIAGNOSTIC INVESTIGATION, 2011, 23 (01) : 26 - 33
  • [7] Chen N. Q., 2015, Jiangxi Journal of Animal Husbandry Veterinary Medicine, V5, P47
  • [8] Global stability and optimal control analysis of a foot-and-mouth disease model with vaccine failure and environmental transmission
    Gashirai, Tinashe B.
    Musekwa-Hove, Senelani D.
    Lolika, Paride O.
    Mushayabasa, Steady
    [J]. CHAOS SOLITONS & FRACTALS, 2020, 132
  • [9] Discrete-time Markov chain approach to contact-based disease spreading in complex networks
    Gomez, S.
    Arenas, A.
    Borge-Holthoefer, J.
    Meloni, S.
    Moreno, Y.
    [J]. EPL, 2010, 89 (03)
  • [10] He W. B., 2007, Hunan Journal of Animal Science Veterinary Medicine, V6, P7