Real-time imaging of mitochondrial redox reveals increased mitochondrial oxidative stress associated with amyloid β aggregates in vivo in a mouse model of Alzheimer’s disease

被引：0
作者：
Maria Calvo-Rodriguez
Elizabeth K. Kharitonova
Austin C. Snyder
Steven S. Hou
Maria Virtudes Sanchez-Mico
Sudeshna Das
Zhanyun Fan
Hamid Shirani
K. Peter R. Nilsson
Alberto Serrano-Pozo
Brian J. Bacskai
机构：
[1] Massachusetts General Hospital and Harvard Medical School,Department of Neurology
[2] Linköping University,Department of Physics, Chemistry and Biology
[3] AbbVie Inc,Present address: Foundational Neuroscience Center
来源：
Molecular Neurodegeneration | / 19卷
关键词：
Oxidative stress; ROS; Alzheimer’s disease; Mitochondria; SS31; Neurodegeneration; Multiphoton microscopy;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
引用
收藏
相关论文
共 442 条
[1]  
Budd Haeberlein S(2022)Two Randomized Phase 3 Studies of Aducanumab in Early Alzheimer's Disease J Prev Alzheimers Dis 9 197-210
[2]  
Aisen PS(2023)Lecanemab in Early Alzheimer's Disease N Engl J Med 388 9-21
[3]  
Barkhof F(2017)Brain aging and neurodegeneration: from a mitochondrial point of view J Neurochem 143 418-431
[4]  
Chalkias S(2006)Decreased plasma antioxidants in patients with Alzheimer's disease Int J Geriatr Psychiatry 21 344-348
[5]  
Chen T(2012)Alzheimer's disease: redox dysregulation as a common denominator for diverse pathogenic mechanisms Antioxid Redox Signal 16 974-1031
[6]  
Cohen S(2007)Targeting antioxidants to mitochondria by conjugation to lipophilic cations Annu Rev Pharmacol Toxicol 47 629-656
[7]  
van Dyck CH(2006)Mitochondria-targeted peptide antioxidants: novel neuroprotective agents AAPS J 8 E521-E531
[8]  
Swanson CJ(2020)Increased mitochondrial calcium levels associated with neuronal death in a mouse model of Alzheimer's disease Nat Commun 11 2146-535
[9]  
Aisen P(2010)Hypoxia triggers subcellular compartmental redox signaling in vascular smooth muscle cells Circ Res 106 526-1148
[10]  
Bateman RJ(2006)Cell-permeable peptide antioxidants as a novel therapeutic approach in a mouse model of amyotrophic lateral sclerosis J Neurochem 98 1141-1496
12345678910