Nuclear accumulation of HDAC4 in ATM deficiency promotes neurodegeneration in ataxia telangiectasia

被引：0
作者：
Jiali Li
Jianmin Chen
Christopher L Ricupero
Ronald P Hart
Melanie S Schwartz
Alexander Kusnecov
Karl Herrup
机构：
[1] Nelson Biological Laboratories,Department of Cell Biology and Neuroscience
[2] Rutgers University,Department of Psychology
[3] Rutgers University,undefined
来源：
Nature Medicine | 2012年 / 18卷
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摘要：
Ataxia-telangiectasia is a multifaceted disease that includes motor dysfunction caused by neuron death in the cerebellum. Now, Karl Herrup and colleagues report that ATM, the gene that is lost in the disease, keeps HDAC4 out of the nucleus and in the cytoplasm to maintain cerebellar neuron health.
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页码：783 / 790
页数：7
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