The Genetics of Pediatric Brain Tumors

被引：0
作者：
Adrian M. Dubuc
Paul A. Northcott
Stephen Mack
Hendrik Witt
Stefan Pfister
Michael D. Taylor
机构：
[1] The Hospital for Sick Children,Division of Neurosurgery, Arthur and Sonia Labatt Brain Tumour Research Centre
[2] The Hospital for Sick Children,Program in Developmental and Stem Cell Biology
[3] University of Toronto,Department of Laboratory Medicine and Pathobiology
[4] German Cancer Research Center,Department of Pediatric Oncology, Hematology and Immunology
[5] Molecular Genetics of Pediatric Brain Tumors,Division of Neurosurgery, Department of Surgery
[6] University of Heidelberg,undefined
[7] Hospital for Sick Children,undefined
来源：
Current Neurology and Neuroscience Reports | 2010年 / 10卷
关键词：
Medulloblastoma; Ependymoma; Supratentorial primitive neuroectodermal tumor; Pilocytic astrocytoma; Genetics; Epigenetics; Cytogenetics; Pediatric brain tumors;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Brain tumors are the most common childhood solid malignancy and the leading cause of cancer-related death in children. Medulloblastoma, ependymoma, supratentorial primitive neuroectodermal tumors, and pilocytic astrocytoma are the most prevalent types, all of which are clinically, histologically, and genetically heterogeneous. Despite an incomplete molecular understanding of these tumors, we have made significant headway in the past 5 years in identifying and classifying important genetic alterations and pathways central to the disease process. This review summarizes our current state of knowledge, emphasizes recent seminal findings in the field, and proposes future research efforts needed to further characterize the genetic basis of pediatric brain tumors.
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页码：215 / 223
页数：8
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