Growth hormone activates PI3K/Akt signaling and inhibits ROS accumulation and apoptosis in granulosa cells of patients with polycystic ovary syndrome

被引：0
|
作者：
Yan Gong
Shan Luo
Ping Fan
Huili Zhu
Yujing Li
Wei Huang
机构：
[1] West China Second University Hospital of Sichuan University,Department of Obstetrics and Gynecology
[2] Ministry of Education,Key Laboratory of Birth Defects and Related Diseases of Women and Children
[3] The Affiliated Women’s and children’s Hospital of Chengdu Medical College,Reproductive Medicine Center, Sichuan Provincial Women’s and Children’s Hospital
[4] Ministry of Education,Laboratory of Genetic Disease and Perinatal Medicine, Key Laboratory of Birth Defects and Related Diseases of Women and Children
[5] West China Second University Hospital of Sichuan University,Department of Reproductive Medicine
来源：
Reproductive Biology and Endocrinology | / 18卷
关键词：
Polycystic ovary syndrome; Growth hormone; Reactive oxygen species; Apoptosis; PI3K/Akt signaling;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
引用
收藏
相关论文
共 50 条
  • [21] Bu-shen-zhu-yun decoction inhibits granulosa cell apoptosis in rat polycystic ovary syndrome through estrogen receptor α-mediated PI3K/AKT/mTOR pathway
    Jiang, Xiaofei
    Yuan, Yizhen
    Shi, Mingqing
    Zhang, Shuang
    Sui, Miao
    Zhou, Huifang
    JOURNAL OF ETHNOPHARMACOLOGY, 2022, 288
  • [22] Role of the PI3K-Akt Signaling Pathway in the Pathogenesis of Polycystic Ovary Syndrome
    Li, Tiantian
    Mo, Hui
    Chen, Wenfeng
    Li, Li
    Xiao, Yao
    Zhang, Jing
    Li, Xiaofang
    Lu, Ying
    REPRODUCTIVE SCIENCES, 2017, 24 (05) : 646 - 655
  • [23] Role of the PI3K-Akt Signaling Pathway in the Pathogenesis of Polycystic Ovary Syndrome
    Tiantian Li
    Hui Mo
    Wenfeng Chen
    Li Li
    Yao Xiao
    Jing Zhang
    Xiaofang Li
    Ying Lu
    Reproductive Sciences, 2017, 24 : 646 - 655
  • [24] Metformin ameliorates polycystic ovary syndrome in a rat model by decreasing excessive autophagy in ovarian granulosa cells via the PI3K/AKT/mTOR pathway
    Xu, Bo
    Dai, Wenjie
    Liu, Ling
    Han, Hang
    Zhang, Jingjing
    Du, Xing
    Pei, Xiuying
    Fu, Xufeng
    ENDOCRINE JOURNAL, 2022, 69 (07) : 863 - 875
  • [25] Decursin inhibits the growth of HeLa cervical cancer cells through PI3K/Akt signaling
    Zhu, Meng-Lian
    Li, Jian-Chun
    Wang, Lu
    Zhong, Xia
    Zhang, Yu-Wei
    Tan, Rui-Zhi
    Wang, Hong-Lian
    Fan, Jun-Ming
    Wang, Li
    JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH, 2021, 23 (06) : 584 - 595
  • [26] Oridonin inhibits oral cancer growth and PI3K/Akt signaling pathway
    Yang, Jing
    Ren, Xianyue
    Zhang, Liping
    Li, Yuanyuan
    Cheng, Bin
    Xia, Juan
    BIOMEDICINE & PHARMACOTHERAPY, 2018, 100 : 226 - 232
  • [27] NTRK2 Promotes Sheep Granulosa Cells Proliferation and Reproductive Hormone Secretion and Activates the PI3K/AKT Pathway
    Jia, Yuhang
    Liu, Yufang
    Wang, Peng
    Liu, Ziyi
    Zhang, Runan
    Chu, Mingxing
    Zhao, Ayong
    ANIMALS, 2024, 14 (10):
  • [28] Protective effects of liquiritin on polycystic ovary syndrome through modulating ovarian granulosa cell proliferation and apoptosis via miR-206/PI3K/AKT pathway
    Cui, Xuan
    Zhou, Shisan
    Lin, Yongtao
    CYTOTECHNOLOGY, 2022, 74 (03) : 385 - 393
  • [29] Protective effects of liquiritin on polycystic ovary syndrome through modulating ovarian granulosa cell proliferation and apoptosis via miR-206/PI3K/AKT pathway
    Xuan Cui
    Shisan Zhou
    Yongtao Lin
    Cytotechnology, 2022, 74 : 385 - 393
  • [30] Downregulation of uPA inhibits migration and PI3k/Akt signaling in glioblastoma cells
    Chandrasekar, N
    Mohanam, S
    Gujrati, M
    Olivero, WC
    Dinh, DH
    Rao, JS
    ONCOGENE, 2003, 22 (03) : 392 - 400
12345