What can knockout mice contribute to an understanding of hypertension?

被引：5
作者：
Audoly L.P. [1 ]
Le T.H. [1 ]
Coffman T.M. [1 ]
机构：
[1] Nephrology, Building 6, Durham VA Medical Center, 508 Fulton Street, Durham
来源：
Current Hypertension Reports | 2000年 / 2卷 / 2期
关键词：
Angiotensinogen; Alter Blood Pressure; Blood Pressure Regulatory Mechanism; Plasma Angiotensinogen Level; Target Gene Duplication;
D O I：
10.1007/s11906-000-0081-4
中图分类号：
学科分类号：
摘要：
The generation of knockout mice using homologous recombination in embryonic stem cells is a powerful tool for physiologic investigations. This experimental approach has provided unique insights into the study of hypertension. Studies using knockout mice have shed new light on blood pressure regulatory mechanisms, molecular mechanisms of end-organ injury, and genetic mechanisms for hypertension. With the development of more accessible approaches for carrying out sophisticated manipulation of the mouse genome, there will be continuing utility of this technique for future studies of hypertension. Copyright © 2000 by Current Science Inc.
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页码：192 / 197
页数：5
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