L protein, the RNA-dependent RNA polymerase of hantaviruses

被引：0
|
作者：
S. K. J. Kukkonen
A. Vaheri
A. Plyusnin
机构：
[1] University of Helsinki,Department of Virology, Haartman Institute
来源：
Archives of Virology | 2005年 / 150卷
关键词：
Infectious Disease; Current Knowledge; Sequence Motif; Endonuclease Activity; Membrane Association;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
L protein of hantaviruses is the RNA transcriptase and replicase that transcribes mRNAs and replicates the genomic RNA using antigenomic RNA as an intermediate. It also appears to have endonuclease activity. In this review, the current knowledge on the hantavirus L protein is presented including sequence motifs conserved in RNA polymerases, mechanisms of RNA synthesis and also the most recent findings on homologous RNA recombination and membrane association.
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页码：533 / 556
页数：23
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