Immunoexpression of p53, Ki-67 and E-cadherin in basaloid squamous cell carcinoma of the larynx

被引：2

作者：

Tojo M.J.R. ^{[1
]}

Cano F.J.G. ^{[2
]}

Sánchez J.C.I. ^{[2
]}

Fernández E.V. ^{[3
]}

Urízar J.M.A. ^{[1
]}

机构：

[1] Unidad de Patología Oral y Maxilofacial, Departamento de Estomatología, Universidad del País Vasco/EHU

[2] Servicio de Otorrinolaringología, Hospital San Millán-San Pedro, Logroño

[3] Servicio de Anatomía Patológica, Hospital San Millán-San Pedro, Logroño

来源：

Clinical and Translational Oncology | 2005年 / 7卷 / 3期

关键词：

Basaloid; Carcinoma; Ecadherin; Ki-67; Larynx; P53;

D O I：

10.1007/BF02708743

中图分类号：

学科分类号：

摘要：

Introduction. Basaloid is a rare and poorly-differentiated variant of squamous cell carcinoma of the larynx, with an invasive solid growth of cells in a lobular configuration. Different molecular markers, such as p53, Ki-67 and E-cadherin, have been shown to be prognostic factors in head and neck cancer. Objective. To evaluate the relationship between the immunoexpression of p53, Ki-67 and E-cadherin in relation to prognosis in basaloid squamous cell carcinoma of the larynx (BSCCL) Patients and methods. We retrospectively studied 11 cases of BSCCL, all male with a mean age of 62.4 years. Immunohistochemical analyses were performed on paraffin-embedded tissues using p53 (DO-7), Ki-67 (MIB-1) and E-cadherin (36B5) antibodies. Quantitative assessments of the expression and descriptive statistical analyses were performed. Results. In 72.7% of the cases, clinically advanced stages III-IV were diagnosed. Average survival time was 56.09 months, and 72.7% of patients died as a consequence of the tumour. Immunoreactivity of p53 (>10% of cells) was detected in the 81.8% of the cases. The 72.7% of the cases showed overexpression of Ki-67 (>50% of cells). The cases with low immunoexpression of Ki-67 and p53 had the best clinico-pathological data. All cases showed a decreased expression of E-cadherin. Conclusions. BSCCL is an aggressive variant of the squamous cell carcinoma and has a high expression of p53 and Ki-67 with a low expression of Ecadherin. These results could be related to the aggressiveness of the disease and its poor prognosis.

引用

页码：110 / 114

页数：4

共 27 条

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