Helicobacter pylori gastritis—Epidemiology

被引:0
作者
Pentti Sipponen
机构
[1] Jorvi Hospital,Department of Pathology
来源
Journal of Gastroenterology | 1997年 / 32卷
关键词
chronic gastritis; peptic ulcer; gastric cancer;
D O I
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中图分类号
学科分类号
摘要
The acquisition ofHelicobacter pylori is the main cause of chronic gastritis in humans. In Europe, a small proportion (less than 1%) of gastritis cases are caused byH. Heilmannii, and somewhat more (5%) are autoimmune in origin, in which conditionH. pylori may not probably play a role. Recent findings on chronic gastritis andH. pylori acquisition in developed countries can be summarized as: (1)H. pylori gastritis is acquired in childhood and adolescence (age less than 20) in more than 50% of cases; (2) the risk and rate of acquisition is highest in early childhood, after which the rate exponentially declines; (3) new infectious occur in adulthood but are quite rare (annual incidence 0.4%, on average, in Finland); (4)H. pylori gastritis is a birth cohort-related phenomenon; i.e., different cohorts show a rate and prevalence ofH. pylori gastritis that varies between cohorts; (5) the rate and risk ofH. pylori infection is high in cohorts born in the beginning of the century, but is much lower in those born later; (6) this decline is due to a decrease in the rate and risk ofH. pylori acquisition in childhood in particular.H. pylori gastritis—related complications, such as peptic ulcer diseases and gastric cancer, show epidemiological features similar toH. pylori gastritis. Both peptic ulcer and gastric cancer have declined in incidence over time. Gastric cancer is a birth-cohort phenomenon in the same way as isH. pylori gastritis, and the incidence of gastric cancer shows a positive but exponential relationship with the “birth-cohort-specific” prevalence of gastritis in the general population.
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页码:273 / 277
页数:4
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共 76 条
[1]  
Price AB(1991)The Sydney System: Histological division J Gastroenterol Hepatol 6 209-222
[2]  
Whitehead R(1972)The histological diagnosis of chronic gastritis in fibreoptic biopsy specimens J Clin Pathol 25 1-11
[3]  
Truelove SC(1985)Chronic gastritis: Dynamic and clinical aspects Scand J Gastroenterol 20 69-76
[4]  
Gear MW(1993)Seroconversion of Lancet 342 328-331
[5]  
Siurala M(1991)The Sydney System: Epidemiology and natural history of chronic gastritis J Gastroenterol Hepatol 6 244-251
[6]  
Sipponen P(1983)Course of antrum and body gastritis in pernicious anemia families Dig Dis Sci 28 698-704
[7]  
Kekki M(1985)The sequelae and course of chronic gastritis during a 30- to 40-year bioptic follow-up study Scand J Gastroenterol 20 485-491
[8]  
Kuipers EJ(1988) in a sample of Finnish population: Relations to morphology and functions of the gastric mucosa Gut 29 909-916
[9]  
Pena AS(1987)Classification principles and genetics of chronic gastritis Scand J Gastroenterol 22 1-28
[10]  
Van Kamp G(1986)Genetic etiology of gastric carcinoma. I. Chronic gastritis Genetic Epidemiol 3 213-224