Spinophilin directs protein phosphatase 1 specificity by blocking substrate binding sites

被引：0
|
作者：
Michael J Ragusa
Barbara Dancheck
David A Critton
Angus C Nairn
Rebecca Page
Wolfgang Peti
机构：
[1] Physiology and Biotechnology,Department of Molecular Pharmacology
[2] Brown University,Department of Molecular Biology
[3] Cell Biology and Biochemistry,Department of Psychiatry
[4] Brown University,undefined
[5] Yale University School of Medicine,undefined
来源：
Nature Structural & Molecular Biology | 2010年 / 17卷
关键词：
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Protein phosphatase specificity is usually achieved via interaction with regulatory partners, which can control their subcellular localization and/or enzymatic specificity. Now structural and functional work on spinophilin reveals its extensive interactions with PP1, which differentially restrict the phosphatase's ability to bind different substrates.
引用
收藏
页码：459 / 464
页数：5
相关论文
共 50 条
  • [41] Altering the substrate specificity of Candida rugosa LIP4 by engineering the substrate-binding sites
    Lee, Li-Chiun
    Chen, Yu-Ting
    Yen, Chih-Chung
    Chiang, Teresa Ching-Yn
    Tang, Shye-Jye
    Lee, Guan-Chiun
    Shaw, Jei-Fu
    JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2007, 55 (13) : 5103 - 5108
  • [42] Molecular Investigations of the Structure and Function of the Protein Phosphatase 1-Spinophilin-Inhibitor 2 Heterotrimeric Complex
    Dancheck, Barbara
    Ragusa, Michael J.
    Allaire, Marc
    Nairn, Angus C.
    Page, Rebecca
    Peti, Wolfgang
    BIOCHEMISTRY, 2011, 50 (07) : 1238 - 1246
  • [43] The β subunit of yeast AMP-activated protein kinase directs substrate specificity in response to alkaline stress
    Chandrashekarappa, Dakshayini G.
    McCartney, Rhonda R.
    O'Donnell, Allyson F.
    Schmidt, Martin C.
    CELLULAR SIGNALLING, 2016, 28 (12) : 1881 - 1893
  • [44] Assessment of protein-tyrosine phosphatase 1B substrate specificity using "inverse alanine scanning"
    Vetter, SW
    Keng, YF
    Lawrence, DS
    Zhang, ZY
    JOURNAL OF BIOLOGICAL CHEMISTRY, 2000, 275 (04) : 2265 - 2268
  • [45] Inhibitor Binding Sites in the Protein Tyrosine Phosphatase SHP-2
    Zhang, Haonan
    Gao, Zhengquan
    Meng, Chunxiao
    Li, Xiangqian
    Shi, Dayong
    MINI-REVIEWS IN MEDICINAL CHEMISTRY, 2020, 20 (11) : 1017 - 1030
  • [46] Involucrin cross-linking by transglutaminase 1 - Binding to membranes directs residue specificity
    Nemes, Z
    Marekov, LN
    Steinert, PM
    JOURNAL OF BIOLOGICAL CHEMISTRY, 1999, 274 (16) : 11013 - 11021
  • [47] The tartrate-resistant purple acid phosphatase of bone osteoclasts - A protein phosphatase with multivalent substrate specificity and regulation
    Andersson, G
    EkRylander, B
    ACTA ORTHOPAEDICA SCANDINAVICA, 1995, 66 : 189 - 194
  • [48] Mutational analysis of substrate recognition by protein phosphatase 1
    Zhang, LF
    Lee, EYC
    BIOCHEMISTRY, 1997, 36 (27) : 8209 - 8214
  • [49] Crystal structure of human TMDP, a testis-specific dual specificity protein phosphatase: Implications for substrate specificity
    Kim, Seung Jun
    Jeong, Dae-Gwin
    Yoon, Tae-Sung
    Son, Jeong-Hee
    Cho, Somi Kim
    Ryu, Seong Eon
    Kim, Jae-Hoon
    PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS, 2007, 66 (01) : 239 - 245
  • [50] INTRINSIC SPECIFICITY OF CA-2+ PROTEIN-BINDING SITES
    REITER, A
    ZHAO, H
    ADAMS, J
    ORGANIC MASS SPECTROMETRY, 1993, 28 (12): : 1596 - 1601
12345