Spinophilin directs protein phosphatase 1 specificity by blocking substrate binding sites

被引：0
|
作者：
Michael J Ragusa
Barbara Dancheck
David A Critton
Angus C Nairn
Rebecca Page
Wolfgang Peti
机构：
[1] Physiology and Biotechnology,Department of Molecular Pharmacology
[2] Brown University,Department of Molecular Biology
[3] Cell Biology and Biochemistry,Department of Psychiatry
[4] Brown University,undefined
[5] Yale University School of Medicine,undefined
来源：
Nature Structural & Molecular Biology | 2010年 / 17卷
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摘要：
Protein phosphatase specificity is usually achieved via interaction with regulatory partners, which can control their subcellular localization and/or enzymatic specificity. Now structural and functional work on spinophilin reveals its extensive interactions with PP1, which differentially restrict the phosphatase's ability to bind different substrates.
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页码：459 / 464
页数：5
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