A statistical approach to detection of copy number variations in PCR-enriched targeted sequencing data

被引:0
作者
German Demidov
Tamara Simakova
Julia Vnuchkova
Anton Bragin
机构
[1] Parseq Lab,Genomic and Epigenomic Variation in Disease Group
[2] Department of Mathematics and Information Technology in SPbAU RAS,undefined
[3] Centre for Genomic Regulation (CRG),undefined
[4] The Barcelona Institute of Science and Technology,undefined
[5] Universitat Pompeu Fabra (UPF),undefined
来源
BMC Bioinformatics | / 17卷
关键词
Machine learning; MPS; Germline CNV; Multiplex PCR; Targeted amplification;
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[1]  
Consugar MB(2015)Panel-based genetic diagnostic testing for inherited eye diseases is highly accurate and reproducible, and more sensitive for variant detection, than exome sequencing Genet Med 17 253-61
[2]  
Chen K(2009)Breakdancer: an algorithm for high-resolution mapping of genomic structural variation Nat Methods 6 677-81
[3]  
Wallis J(2009)Combinatorial algorithms for structural variation detection in high-throughput sequenced genomes Genome Res 19 1270-8
[4]  
McLellan M(2014)Evaluation of copy number variation detection for a snp array platform BMC Bioinforma 10 1-9
[5]  
Larson D(2007)Genetic variation in human disease and a new role for copy number variants Mutat Res 622 33-41
[6]  
Kalicki J(2009)Mechanisms of change in gene copy number Nat Rev Genet 10 551-64
[7]  
Pohl C(2009)Genetic association analysis of copy-number variation (cnv) in human disease pathogenesis Genomics 93 22-6
[8]  
McGrath S(2009)Copy number variation in human health, disease, and evolution Annu Rev Genomics Hum Genet 10 451-81
[9]  
Wendl M(2013)Computational tools for copy number variation (cnv) detection using next-generation sequencing data: features and perspectives BMC Bioinforma 14 1-6
[10]  
Zhang Q(2014)Inferring copy number and genotype in tumour exome data BMC Genomics 15 732-54