Erythrocyte antioxidants in aging and dementia

被引:0
作者
E. A. Kosenko
L. A. Tikhonova
A. S. Pogosyan
Yu. G. Kaminsky
机构
[1] Russian Academy of Sciences,Institute of Theoretical and Experimental Biophysics
[2] Pushchino State University,Hospital at the Pushchino Scientific Center
[3] Russian Academy of Sciences,undefined
关键词
Alzheimer’s disease; aging; erythrocytes; oxidative stress; antioxidants;
D O I
10.1134/S1990750812030079
中图分类号
学科分类号
摘要
Age of patients and oxidative stress in brain cells may contribute to pathogenesis of Alzheimer’s disease (AD). Erythrocytes (red blood cells, RBC) are considered as passive “reporter cells” for the oxidative status of the whole body and remain poorly investigated in AD. The aim of this study was to assess whether the antioxidant status of RBC changes in aging and AD. Blood was taken from AD and non-Alzheimer’s dementia patients, aged-matched and younger controls. The antioxidant status of RBC was evaluated in each person participated in the study by measuring levels of H2O2, organic hydroperoxides, glutathione (GSH) and glutathione disulfide (GSSG), activities of superoxide dismutase, catalase, glutathione peroxidase, glutathione reductase, glutathione S-transferase, and glucose-6-phosphate dehydrogenase. In both aging and dementia, oxidative stress in RBC was shown to increase as evidenced by elevated concentrations of H2O2, organic hydroperoxides, decreased GSH/GSSG ratio, and decreased glutathione S-transferase activity. Decreased glutathione peroxidase activity in RBC may be considered as a new peripheral marker for Alzheimer’s disease while changes of other parameters of oxidative stress reflect age-related events.
引用
收藏
页码:273 / 277
页数:4
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