Allogeneic hematopoietic cell transplantation in adult acute myeloid leukemia with 11q23 abnormality: a retrospective study of the Adult Acute Myeloid Leukemia Working Group of the Japan Society for Hematopoietic Cell Transplantation (JSHCT)

被引：0

作者：

Takaaki Konuma

Shohei Mizuno

Tadakazu Kondo

Hiroki Yamaguchi

Takahiro Fukuda

Naoyuki Uchida

Yuho Najima

Heiwa Kanamori

Shuichi Ota

Hirohisa Nakamae

Mika Nakamae

Ishikazu Mizuno

Junichi Sugita

Yasushi Onishi

Akira Yokota

Satoshi Takahashi

Yoshinobu Kanda

Tatsuo Ichinohe

Yoshiko Atsuta

Shingo Yano

机构：

[1] The University of Tokyo,Department of Hematology/Oncology, The Institute of Medical Science

[2] Aichi Medical University,Division of Hematology, Department of Internal Medicine, School of Medicine

[3] Kyoto University,Department of Hematology and Oncology, Graduate School of Medicine

[4] Nippon Medical School,Department of Hematology

[5] National Cancer Center Hospital,Department of Hematopoietic Stem Cell Transplantation

[6] Federation of National Public Service Personnel Mutual Aid Associations Toranomon Hospital,Department of Hematology

[7] Komagome Hospital,Hematology Division, Tokyo Metropolitan Cancer and Infectious Diseases Center

[8] Kanagawa Cancer Center,Department of Hematology

[9] Sapporo Hokuyu Hospital,Department of Hematology

[10] Osaka City University,Hematology, Graduate School of Medicine

[11] Hyogo Cancer Center,Department of Hematology

[12] Hokkaido University Graduate School of Medicine,Department of Hematology

[13] Tohoku University Hospital,Department of Hematology and Rheumatology

[14] Chiba Aoba Municipal Hospital,Department of Hematology

[15] The University of Tokyo,Division of Molecular Therapy, The Advanced Clinical Research Center, The Institute of Medical Science

[16] Jichi Medical University,Division of Hematology

[17] Saitama Medical Center,Department of Hematology and Oncology, Research Institute for Radiation Biology and Medicine

[18] Hiroshima University,Department of Healthcare Administration

[19] Japanese Data Center for Hematopoietic Cell Transplantation,Division of Clinical Oncology and Hematology, Department of Internal Medicine

[20] Nagoya University Graduate School of Medicine,undefined

[21] Jikei University School of Medicine,undefined

来源：

Annals of Hematology | 2018年 / 97卷

关键词：

11q23 abnormality; Mixed lineage leukemia; Lysine-specific methyltransferase 2A; Acute myeloid leukemia; Allogeneic hematopoietic cell transplantation; Minimal residual disease; Adult;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

An 11q23 abnormality presents in approximately 5% of adults with acute myeloid leukemia (AML) and is associated with adverse outcomes even after allogeneic hematopoietic cell transplantation (allo-HCT). To evaluate the outcomes and prognostic factors following allo-HCT for adult AML with 11q23 abnormality, we retrospectively analyzed the Japanese registration data of 322 adult AML patients with 11q23 abnormality who had received allo-HCT between 1990 and 2014. In total, the disease status at HCT was first complete remission (CR1) in 159 (49%) patients. The probability of overall survival and the cumulative incidence of relapse at 3 years were 44 and 44%, respectively. In the multivariate analysis, disease status beyond CR1 at the time of HCT was significantly associated with a higher overall mortality and relapse. The 11q23 fusion partner did not have a significant impact on survival. We also evaluated the prognostic value of minimal residual disease (MRD) status at HCT on transplant outcomes among hematological CR patients. MRD status at HCT was the significant prognostic indicator for hematological relapse and survival. These data suggested that allo-HCT offered a curative option for adult AML with 11q23 abnormality. Pretransplant MRD status was the significant prognostic indicator for relapse and survival in CR patients.

引用

页码：2173 / 2183

页数：10

共 439 条

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