Virulence determinants in Staphylococcus aureus and their involvement in clinical syndromes

被引：76
作者：
Ferry T. [1 ]
Perpoint T. [1 ]
Vandenesch F. [1 ]
Etienne J. [1 ]
机构：
[1] Centre National de Référence des Staphylocoques, INSERM E0230, Faculté de Médecine Laennec, 69008 Lyon
来源：
Current Infectious Disease Reports | 2005年 / 7卷 / 6期
关键词：
Septic Shock; Virulence Factor; Infective Endocarditis; Toxic Shock Syndrome; Purpura Fulminans;
D O I：
10.1007/s11908-005-0043-8
中图分类号：
学科分类号：
摘要：
Staphylococcus aureus is a major human pathogen responsible for a variety of toxin-mediated and suppurative diseases. About 50 staphylococcal virulence factors have been described to date. In this review, we examine the crinicali implications of key staphylococcal virulence factors in toxin-mediated diseases, septic shock, and severe focal infections such arthritis, infective endocarditis, pneumonia acquired during mechanical ventilatton, and necrotizing pneumonia. Staphylococcal pathogenicity is sometimes due principally to a single virulence factor, as in, toxic shock syndrome and necrotizing pneumonia. In contrast, several virulence factors are involved in other staphylococcal disease, such as septic shock. A better knowledge of the mechanism of action of each virulence factor involved in the different staphylococcal diseases could open the way to the use of specific inhibitors in the clinical setting. Copyright © 2005 by Current Science Inc.
引用
收藏
页码：420 / 428
页数：8
相关论文
共 52 条
[1]  
Baba T., Takeuchi F., Kuroda M., Et al., Genome and virulence determinants of high virulence community-acquired MRSA, Lancet, 359, pp. 1819-1827, (2002)
[2]  
Lowy F.D., Staphylococcus aureus infections, N. EngI. J. Med., 339, pp. 520-532, (1998)
[3]  
Cheung A.L., Projan S.J., Gresham H., The genomic aspect of virulence, sepsis, and resistance to killing mechanisms in Staphylococcus aureus, Curr. Infect. Dis. Rep., 4, pp. 400-410, (2002)
[4]  
Astiz M.E., Rackow E.C., Septic shock, Lancet, 351, pp. 1501-1505, (1998)
[5]  
Dinges M.M., Orwin P.M., Schlievert P.M., Exotoxins of Staphylococcus aureus, Clin. Microbiol. Rev., 13, pp. 16-34, (2000)
[6]  
Robbins J.B., Schneerson R., Horwith G., Et al., Staphylococcus aureus types 5 and 8 capsular polysaccharide-protein conjugate vaccines, Am. Heart J., 147, pp. 593-598, (2004)
[7]  
Foster T.J., Hook M., Surface protein adhesins of Staphylococcus aureus, Trends Microbiol., 6, pp. 484-488, (1998)
[8]  
Silverman G.J., Goodyear C.S., A model B-cell superantigen and the immunobiology of B lymphocytes, Clin. Immunol., 102, pp. 117-134, (2002)
[9]  
Gomez M.I., Lee A., Reddy B., Et al., Staphylococcus aureus protein A induces airway epithelial inflammatory responses by activating TNFR1, Nat. Med., 10, pp. 842-848, (2004)
[10]  
Lina G., Bohach G.A., Nair S.P., Et al., Standard nomenclature for the superantigens expressed by Staphylococcus, J. Infect. Dis., 189, pp. 2334-2336, (2004)
123456