A reason why the ERBB2 gene is amplified and not mutated in breast cancer

被引：0
作者：
Daniel Birnbaum
Fabrice Sircoulomb
Jean Imbert
机构：
[1] UMR891 Inserm and Institut Paoli-Calmettes,Centre de Recherche en Cancérologie de Marseille
[2] Université de la Méditerranée,undefined
[3] Marseille,undefined
[4] U928 Inserm,undefined
[5] TAGC,undefined
[6] Marseille-Luminy,undefined
来源：
Cancer Cell International | / 9卷
关键词：
Breast Cancer; Mammary Epithelial Cell; ERBB2 Expression; ERBB2 Gene; ERBB2 Protein;
D O I：
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摘要：
Alterations of receptor-type tyrosine kinases (RTK) are frequent in human cancers. They can result from translocation, mutation or amplification. The ERBB2 RTK is encoded by a gene that is amplified in about 20% breast cancers. The question is: why is this RTK specifically subjected to this type of alteration? We propose that ERBB2 gene amplification is used to overcome repression of its expression by sequence-specific transcription factors.
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  • [1] Slamon DJ(1987)Human breast cancer: correlation of relapse and survival with amplification of the HER-2/neu oncogene Science 235 177-182
  • [2] Clark GM(2007)Identification of the transforming EML4-ALK fusion gene in non-small-cell lung cancer Nature 448 561-566
  • [3] Wong SG(2008)Identification of ALK as a major familial neuroblastoma predisposition gene Nature 455 930-935
  • [4] Levin WJ(2008)Somatic and germline activating mutations of the ALK kinase receptor in neuroblastoma Nature 455 967-970
  • [5] Ullrich A(2008)Oncogenic mutations of ALK kinase in neuroblastoma Nature 455 971-974
  • [6] McGuire WL(2008)Activating mutations in ALK provide a therapeutic target in neuroblastoma Nature 455 975-978
  • [7] Soda M(2007)FOXP3 Is an X-Linked Breast Cancer Suppressor Gene and an Important Repressor of the HER-2/ErbB2 Oncogene Cell 129 1275-1286
  • [8] Choi YL(2008)Regulation of ERBB2 by oestrogen receptor-PAX2 determines response to tamoxifen Nature 456 663-666
  • [9] Enomoto M(2000)The ets protein PEA3 suppresses HER-2/neu overexpression and inhibits tumorigenesis Nat Med 6 189-195
  • [10] Takada S(1995)c-Myb repression of c-erbB-2 transcription by direct binding to the c-erbB-2 promoter J Biol Chem 270 9384-9389
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