A reason why the ERBB2 gene is amplified and not mutated in breast cancer

被引:0
作者
Daniel Birnbaum
Fabrice Sircoulomb
Jean Imbert
机构
[1] UMR891 Inserm and Institut Paoli-Calmettes,Centre de Recherche en Cancérologie de Marseille
[2] Université de la Méditerranée,undefined
[3] Marseille,undefined
[4] U928 Inserm,undefined
[5] TAGC,undefined
[6] Marseille-Luminy,undefined
来源
Cancer Cell International | / 9卷
关键词
Breast Cancer; Mammary Epithelial Cell; ERBB2 Expression; ERBB2 Gene; ERBB2 Protein;
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摘要
Alterations of receptor-type tyrosine kinases (RTK) are frequent in human cancers. They can result from translocation, mutation or amplification. The ERBB2 RTK is encoded by a gene that is amplified in about 20% breast cancers. The question is: why is this RTK specifically subjected to this type of alteration? We propose that ERBB2 gene amplification is used to overcome repression of its expression by sequence-specific transcription factors.
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