The nature of fibrous dysplasia

被引：66

作者：

Feller L. ^{[1
]}

Wood N.H. ^{[1
]}

Khammissa R.A. ^{[1
]}

Lemmer J. ^{[1
]}

Raubenheimer E.J. ^{[2
]}

机构：

[1] Department of Periodontology and Oral Medicine, School of Dentistry, University of Limpopo (Medunsa Campus), Pretoria

[2] Department of Oral Pathology, School of Dentistry, University of Limpopo (Medunsa Campus), Pretoria

来源：

Head & Face Medicine | / 5卷 / 1期

关键词：

Acromegaly; Fibrous Dysplasia; Osteogenic Cell; Bony Lesion; Craniofacial Bone;

D O I：

10.1186/1746-160X-5-22

中图分类号：

学科分类号：

摘要：

Fibrous dysplasia has been regarded as a developmental skeletal disorder characterized by replacement of normal bone with benign cellular fibrous connective tissue. It has now become evident that fibrous dysplasia is a genetic disease caused by somatic activating mutation of the Gs subunit of G protein-coupled receptor resulting in upregulation of cAMP. This leads to defects in differentiation of osteoblasts with subsequent production of abnormal bone in an abundant fibrous stroma. In addition there is an increased production of IL-6 by mutated stromal fibrous dysplastic cells that induce osteoclastic bone resorption. © 2009 Feller et al.

引用

共 20 条

[1]

Neville B.W., Damm D.D., Allan C.M., Bouquot J.E., Bone Pathology, Oral and Maxillofacial Pathology, pp. 635-640, (2002)

[2]

Abdel-Wanis M.E., Tsuchiya H., Melatonin deficiency and fibrous dysplasia: Might a relation exist?, Med Hypotheses, 59, pp. 552-554, (2002)

[3]

Faves M.J., Vokes T.J., Paget disease and other dysplasias of bone, Harrison's Principles of Internal Medicine, pp. 2279-2286, (2005)

[4]

Alam W., Cdr A., Chander G., Capt B.N., Craniofacial fibrous dysplasia presenting with visual impairment, MJAFI, 59, pp. 342-343, (2003)

[5]

Yetiser S., Gonul E., Tosun F., Tasar M., Hidir Y., Monostotic craniofacial fibrous dysplasia: The Turkish experience, Journal of Craniofacial Surgery, 17, 1, pp. 62-67, (2006)

[6]

Riminucci M., Saggio I., Robey P.G., Bianco P., Fibrous dysplasia as a stem cell disease, J Bone and Mineral Res, 21, (2006)

[7]

Ogunsalu C.O., Lewis A., Doonquah L., Benign fibro-osseous lesions of the jaw bones in Jamaica: Analysis of 32 cases, Oral Dis, 7, pp. 155-162, (2001)

[8]

Lustig L.R., Holliday M.J., McCarthy E.F., Nager G.T., Fibrous dysplasia involving the skull base and temporal bone, Arch Otolaryngol Head Neck Surg, 127, pp. 1239-1247, (2001)

[9]

Panda N.K., Parida P.K., Sharma R., Jain A., Bapuraj J.R., A clinicoradiologic analysis of symptomatic craniofacial fibro-osseous lesions, Otolaryngol Head Neck Surg, 136, pp. 928-933, (2007)

[10]

Riminucci M., Kuznetsov S.A., Cherman N., Corsi A., Bianco P., Gehron Robey P., Osteoclastogenesis in fibrous dysplasia of bone: In situ and in vitro analysis of IL-6 expression, Bone, 33, pp. 434-442, (2003)

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