Molecular Communication from Skeletal Muscle to Bone: A Review for Muscle-Derived Myokines Regulating Bone Metabolism

被引：0
作者：
Baosheng Guo
Zong-Kang Zhang
Chao Liang
Jie Li
Jin Liu
Aiping Lu
Bao-Ting Zhang
Ge Zhang
机构：
[1] Hong Kong Baptist University,Institute for Advancing Translational Medicine in Bone and Joint Diseases, School of Chinese Medicine
[2] The Chinese University of Hong Kong,School of Chinese Medicine
来源：
Calcified Tissue International | 2017年 / 100卷
关键词：
Skeletal muscle; Bone; Myokines;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Besides the mechanical loading-dependent paradigm, skeletal muscle also serves as an endocrine organ capable of secreting cytokines to modulate bone metabolism. In this review, we focused on reviewing the myokines involved in communication from skeletal muscle to bone, i.e. (1) myostatin and myostatin-binding proteins including follistatin and decorin, (2) interleukins including interleukin-6 (IL-6), interleukin-7 (IL-7) and interleukin-15 (IL-15), (3) insulin-like growth factor 1 (IGF-1) and its binding proteins, (4) other myokines including PGC-1α-irisin system and osteoglycin (OGN). To better understand the molecular communication from skeletal muscle to bone, we have summarized the recent advances in muscle-derived cytokines regulating bone metabolism in this review.
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页码：184 / 192
页数：8
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