p-chloroamphetamine- and d-fenfluramine-induced brain serotonin release in experimental portal-systemic encephalopathy

被引：0

作者：

Bergqvist P.B.F. ^{[1
,3
]}

Hjorth S. ^{[2
]}

Wikell C. ^{[1
]}

Apelqvist G. ^{[1
]}

Bengtsson F. ^{[1
]}

机构：

[1] Department of Clinical Pharmacology, Institute of Laboratory Medicine, Lund University, Lund

[2] Department Pharmacology, University of Gothenburg, Gothenburg

[3] Department of Clinical Pharmacology, Institute of Laboratory Medicine, Lund University Hospital

来源：

Metabolic Brain Disease | 1997年 / 12卷 / 3期

关键词：

d-fenfluramine; Hepatics encephalopathy; p-chloroamphetamine; Portacaval shunt; Release; Serotonin;

D O I：

10.1023/B:MEBR.0000007103.82267.06

中图分类号：

学科分类号：

摘要：

Portal-systemic encephalopathy (PSE) is associated with increased brain turnover of serotonin (5-HT)/n vivo but the brain 5-HT output seems to be unaltered. Recent results suggest, however, that an augmented neocortical 5- HT release in experimental chronic PSE may prevail under certain conditions. In the present study, neocortical extracellular 5-HT and 5- hydroxyindoleacetic-3-acid (5-HIAA) levels were measured in portacaval shunted (PCS) rats and sham-operated controls following local administration of p-chloroamphetamine (pCA) and d-fenfluramine (dFEN), two specific 5-HT releasing agents. The basal neocortical extracellular 5-HT concentrations were unaltered and the 5-HIAA levels were elevated in experimental PSE, supporting an unchanged brain 5-HT output despite elevated brain 5-HT metabolism. Perfusion with pCA or dFEN (5 μM; one 20-min pulse) produced marked increases in brain 5-HT release both in ECS and sham-operated rats compared with corresponding basal values. While no difference in the 5-HT response to dFEN administration was seen between sham (5-HT levels increased by 330%) and PCS (500%) rats, a clear difference (p<0.05) in the brain 5-HT output was observed between the two experimental groups following pCA perfusion (sham, 1100% versus PCS, 1470%). These results support our previous contention of an enhanced neocortical 5-HT output in experimental chronic PSE under certain pharmacological conditions.

引用

页码：229 / 236

页数：7

共 23 条

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