Universal screening for Lynch syndrome among patients with colorectal cancer: patient perspectives on screening and sharing results with at-risk relatives

被引:0
作者
Jessica Ezzell Hunter
Kathleen A. Arnold
Jennifer E. Cook
Jamilyn Zepp
Marian J. Gilmore
Alan F. Rope
James V. Davis
Kellene M. Bergen
Elizabeth Esterberg
Kristin R. Muessig
Susan K. Peterson
Sapna Syngal
Louise Acheson
Georgia Wiesner
Jacob Reiss
Katrina A. B. Goddard
机构
[1] Center for Health Research,Department of Behavioral Science
[2] Kaiser Permanente Northwest,Dana
[3] The University of Texas MD Anderson Cancer Center,Farber Cancer Institute
[4] Brigham and Women’s Hospital,Departments of Family Medicine and Community Health, Reproductive Biology, and Oncology
[5] Harvard Medical School,Vanderbilt Hereditary Cancer Program, Department of Medicine, Vanderbilt
[6] Case Western Reserve University,Ingram Cancer Center
[7] Vanderbilt University,undefined
来源
Familial Cancer | 2017年 / 16卷
关键词
Lynch syndrome; HNPCC; Colorectal cancer; Genetic screening; Genetic testing; Microsatellite instability;
D O I
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中图分类号
学科分类号
摘要
Universal screening for Lynch syndrome (LS) among all cases of colorectal cancer (CRC) could increase the diagnosis of LS and reduce morbidity and mortality of LS-associated cancers. Given universal screening includes all patients, irrespective of high risk factors such early age at onset or family history of CRC, it is important to understand perspectives of all patients and not just those at high risk. As part of a study to assess the feasibility and implementation of universal screening, 189 patients newly diagnosed with CRC were surveyed about their interest in screening for LS and communication of results with at-risk family members. Overall, participants responded positively regarding screening for LS, with most wanting to know their genetic risks in general (86%) and risk of hereditary CRC (93%). Prior to receiving screening results, most participants stated they intended to share their screening results with parents (89%), siblings (96%), and children (96%). Of the 28 participants who received a positive LS screening result, 26 (93%) reported sharing their result with at least one first-degree family member. Interest in screening for LS and communication of screening results with family members was not associated with high risk factors. This study indicates that patients are interested in being screened for LS and that sharing information on the risk of LS with at-risk family members is not a significant barrier. These findings provide novel insight into patient perspectives about screening for LS and can guide successful implementation of universal screening programs.
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页码:377 / 387
页数:10
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