Anti-inflammatory activity of superoxide dismutase conjugated with sodium hyaluronate

被引：0

作者：

Katsukiyo Sakurai

Kyousuke Miyazaki

Yoh Kodera

Hiroyuki Nishimura

Masao Shingu

Yuji Inada

机构：

[1] Toin University of Yokohama,Toin Human Science and Technology Centre, Department of Materials Science and Technology

[2] Seikagaku Corporation,The Tokyo Research Institute

[3] Kyushu University,Department of Internal Medicine, Medical Institute of Bioregulation

来源：

Glycoconjugate Journal | 1997年 / 14卷

关键词：

superoxide dismutase; sodium hyaluronate; glycoconjugate; ischemic oedema; carrageenin-induced pleurisy; adjuvant arthritis;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

Superoxide dismutase (SOD) from bovine erythrocytes was conjugated with sodium hyaluronate (HA) with a mean molecular weight of 106 to have greater anti-inflammatory activity in vivo. Amino groups of SOD were coupled with carboxyl groups in the hyaluronate molecule using 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide. The HA-SOD conjugate was composed of 1.5 mol of SOD molecule per 1 mol of hyaluronate on the average, and retained 70% of the activity of unmodified SOD. The conjugate was essentially non-immunogenic in mice, and exhibited much higher anti-inflammatory activities than HA or SOD in models of inflammatory diseases such as ischemic oedema of the foot-pad in mice, carrageenin-induced pleurisy and adjuvant arthritis in rats.

引用

页码：723 / 728

页数：5

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