DNMT3A and TET2 mutations reshape hematopoiesis in opposing ways

被引：0
|
作者：
Isaac F. López-Moyado
Anjana Rao
机构：
[1] La Jolla Institute for Immunology,Division of Signaling and Gene Expression
[2] Sanford Consortium for Regenerative Medicine,Department of Pharmacology and Moores Cancer Center
[3] University of California San Diego,undefined
来源：
Nature Genetics | 2020年 / 52卷
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摘要：
TET2 and DNMT3A mutations lead to similar long-term outcomes in blood cancers despite the antagonistic biochemical functions of their encoded proteins. A new study highlights the opposing effects of TET2 and DNMT3A mutations in shaping the early erythroid or myeloid bias of hematopoietic progenitors.
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页码：554 / 556
页数：2
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