DNMT3A and TET2 mutations reshape hematopoiesis in opposing ways

被引：0

作者：

Isaac F. López-Moyado

Anjana Rao

机构：

[1] La Jolla Institute for Immunology,Division of Signaling and Gene Expression

[2] Sanford Consortium for Regenerative Medicine,Department of Pharmacology and Moores Cancer Center

[3] University of California San Diego,undefined

来源：

Nature Genetics | 2020年 / 52卷

关键词：

D O I：

暂无

中图分类号：

学科分类号：

摘要：

TET2 and DNMT3A mutations lead to similar long-term outcomes in blood cancers despite the antagonistic biochemical functions of their encoded proteins. A new study highlights the opposing effects of TET2 and DNMT3A mutations in shaping the early erythroid or myeloid bias of hematopoietic progenitors.

引用

页码：554 / 556

页数：2

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