4-Hydroxy-2-quinolones 148. Synthesis and antitubercular activity of 1-hydroxy-3-oxo-6,7-dihydro-3H,5H-pyrido[3,2,1-ij]quinoline-2-carboxylic acid N-R-amides

被引：0

作者：

I. V. Ukrainets

A. A. Tkach

L. A. Grinevich

机构：

[1] National University of Pharmacy,

来源：

Chemistry of Heterocyclic Compounds | 2008年 / 44卷

关键词：

hetarylamides; 4-hydroxy-2-oxoquinoline-3-carboxylic acids; amidation; antitubercular activity; X-ray structural analysis;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

An improved method for the preparation of ethyl 1-hydroxy-3-oxo-6,7-dihydro-3H,5H-pyrido[3,2,1-ij]quinoline-2-carboxylate has been proposed and a series of hetarylamides has been synthesized from it. A comparative analysis has been carried out of the antitubercular activities of the synthesized compounds with the active structural analogs 4-hydroxy-2-oxo-1,2-dihydroquinoline-3 and 1-hydroxy-3-oxo-5,6-dihydro-3H-pyrrolo[3,2,1-ij]quinoline-2-carboxamides studied before.

引用

共 50 条

[21] 4-hydroxy-2-quinolones - 140. Synthesis and diuretic activity of arylalkylamides of 4-methyl-2-oxo-1,2-dihydro-quinoline-3-carboxylic acid
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