4-Hydroxy-2-quinolones 148. Synthesis and antitubercular activity of 1-hydroxy-3-oxo-6,7-dihydro-3H,5H-pyrido[3,2,1-ij]quinoline-2-carboxylic acid N-R-amides

被引：0

作者：

I. V. Ukrainets

A. A. Tkach

L. A. Grinevich

机构：

[1] National University of Pharmacy,

来源：

Chemistry of Heterocyclic Compounds | 2008年 / 44卷

关键词：

hetarylamides; 4-hydroxy-2-oxoquinoline-3-carboxylic acids; amidation; antitubercular activity; X-ray structural analysis;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

An improved method for the preparation of ethyl 1-hydroxy-3-oxo-6,7-dihydro-3H,5H-pyrido[3,2,1-ij]quinoline-2-carboxylate has been proposed and a series of hetarylamides has been synthesized from it. A comparative analysis has been carried out of the antitubercular activities of the synthesized compounds with the active structural analogs 4-hydroxy-2-oxo-1,2-dihydroquinoline-3 and 1-hydroxy-3-oxo-5,6-dihydro-3H-pyrrolo[3,2,1-ij]quinoline-2-carboxamides studied before.

引用

共 50 条

[1] 4-HYDROXY-2-QUINOLONES 148. SYNTHESIS AND ANTI-TUBERCULAR ACTIVITY OF 1-HYDROXY-3-OXO-6,7-DIHYDRO-3H,5H-PYRIDO[3,2,1-ij]QUINOLINE-2-CARBOXYLIC ACID N-R-AMIDES
Ukrainets, I. V.
Tkach, A. A.
Grinevich, L. A.
CHEMISTRY OF HETEROCYCLIC COMPOUNDS, 2008, 44 (08) : 956 - 966
[2] 4-hydroxy-2-quinolones. 108. N-R-amides of 9-fluoro-1-hydroxy-5-methyl-3- oxo-6,7-dihydro-3H,5H-pyrido[3,2,1-ij]quinoline-2-carboxylic acid and their antitubercular activity
Ukrainets I.V.
Sidorenko L.V.
Gorokhova O.V.
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Chemistry of Heterocyclic Compounds, 2006, 42 (9) : 1208 - 1222
[3] 4-Hydroxy-2-quinolones. 194*. 1-Hydroxy-3-oxo-6,7-dihydro-3H,5H-pyrido[3,2,1-ij]quinoline-2-carboxylic acid alkylamides. Synthesis, structure, and biological properties
I. V. Ukrainets
N. Yu. Golik
K. V. Andreeva
O. V. Gorokhova
Chemistry of Heterocyclic Compounds, 2011, 46
[4] 4-HYDROXY-2-QUINOLONES. 194. 1-HYDROXY-3-OXO-6,7-DIHYDRO-3H,5H-PYRIDO[3,2,1-ij]QUINOLINE-2-CARBOXYLIC ACID ALKYLAMIDES. SYNTHESIS, STRUCTURE, AND BIOLOGICAL PROPERTIES
Ukrainets, I. V.
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CHEMISTRY OF HETEROCYCLIC COMPOUNDS, 2011, 46 (12) : 1459 - 1466
[5] 4-Hydroxy-2-quinolones 121. Synthesis and biological properties of 1-hydroxy-3-oxo-5,6-dihydro-3H-pyrrolo[3,2,1-ij]quinoline-2-carboxylic acid alkylamides
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Bereznyakova N.L.
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[6] 4-Hydroxy-2-quinolones 126. 1-Hydroxy-3-oxo-5,6-dihydro-3H-pyrrolo[3,2,1- ij]quinoline-2-carboxylic acid hydrazide and its derivatives
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[7] 4-Hydroxy-2-quinolones. 122. 1-Hydroxy-3-oxo-5,6-dihydro-3H-pyrrolo[3,2,1- ij]-quinoline-2-carboxylic acid hetarylamides as potential antitubercular agents
Ukrainets I.V.
Mospanova E.V.
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Chemistry of Heterocyclic Compounds, 2007, 43 (7) : 863 - 870
[8] 4-Hydroxy-2-quinolones 138. Synthesis and study of structure-biological activity relationships in a series of 1-hydroxy-3-oxo-5,6-dihydro-3H-pyrrolo[3, 2,1-ij]quinoline-2-carboxylic acid anilides
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[9] 4-Hydroxy-2-quinolones 171*. Synthesis, isomerism, and antitubercular activity of 1-R-4-hydroxy-2-oxo-1,2-dihydro-quinoline-3-carboxylic acid alkylidenehydrazides
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[10] 4-HYDROXY-2-QUINOLONES 171*. SYNTHESIS, ISOMERISM, AND ANTITUBERCULAR ACTIVITY OF 1-R-4-HYDROXY-2-OXO-1,2-DIHYDRO-QUINOLINE-3-CARBOXYLIC ACID ALKYLIDENEHYDRAZIDES
Ukrainets, I. V.
Liu Yangyang
Tkach, A. A.
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CHEMISTRY OF HETEROCYCLIC COMPOUNDS, 2009, 45 (11) : 1335 - 1342

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