Two New Bisorbicillinoids Isolated from a Deep-sea Fungus, Phialocephala sp. FL30r

被引：0
作者：
Dehai Li
Fengping Wang
Shengxin Cai
Xiang Zeng
Xiang Xiao
Qianqun Gu
Weiming Zhu
机构：
[1] Key Laboratory of Marine Drugs,
[2] Chinese Ministry of Education,undefined
[3] Institute of Marine Drugs and Food,undefined
[4] Ocean University of China,undefined
[5] Key Laboratory of Marine Biogenetic Resources,undefined
[6] Third Institute of Oceanography,undefined
[7] The State Oceanic Administration,undefined
来源：
The Journal of Antibiotics | 2007年 / 60卷
关键词：
bisorbicillinoids; deep-sea fungus; sp.; cytotoxicity;
D O I：
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中图分类号：
学科分类号：
摘要：
Two new bisorbicillinoids, named oxosorbiquinol (1) and dihydrooxosorbiquinol (2), were isolated from a deep-sea fungus, Phialocephala sp., and their structures established using spectroscopic methods. The absolute configurations of 1 and 2 were determined by their biosynthesis route and analysis of the CD spectrum. Their cytotoxic effects on P388, A-549, HL60, BEL7402 and K562 cell lines were examined by the MTT method.
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页码：317 / 320
页数：3
相关论文
共 32 条
[1]  
Bringmanna G(2005)The first sorbicillinoid alkaloids, the antileukemic sorbicillactones A and B, from a sponge-derived Tetrahedron 61 7252-7265
[2]  
Lang G(2005) strain J Antibiot 58 441-446
[3]  
Gulder TAM(1983)Two new benzoquinone derivatives and two new bisorbicillinoids were isolated from a marine-derived fungus J Immunol Methods 65 55-63
[4]  
Tsuruta H(1992)Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays Can J Chem 70 2526-2535
[5]  
Muhlbacher J(1997)The metabolites of Aust J Chem 50 255-258
[6]  
Maksimenka K(1996). Part I. Isolation of the metabolites and the structure of trichodimerol Can J Chem 74 371-379
[7]  
Steffens S(2000)The metabolites of Biosci Biotechol Biochem 64 620-622
[8]  
Schaumann K(undefined). III. Two new tetronic acids: 5-hydroxyvertinolide and bislongiquinolide undefined undefined undefined-undefined
[9]  
Stohr R(undefined)The metabolites of undefined undefined undefined-undefined
[10]  
Wiese J(undefined). Part II. The structures of trichodermolide and sorbiquinol undefined undefined undefined-undefined
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