Influence of sex, age, pubertal maturation and body mass index on circulating white blood cell counts in healthy European adolescents—the HELENA study

被引：0
作者：
Fátima Pérez-de-Heredia
Sonia Gómez-Martínez
Ligia-Esperanza Díaz
Ana M. Veses
Esther Nova
Julia Wärnberg
Inge Huybrechts
Krishna Vyncke
Odysseas Androutsos
Marika Ferrari
Gonzalo Palacios
Acki Wastlund
Éva Kovács
Frédéric Gottrand
Marcela González-Gross
Manuel J. Castillo
Michael Sjöstrom
Yannis Manios
Anthony Kafatos
Denes Molnár
Kurt Widhalm
Luis A. Moreno
Ascensión Marcos
机构：
[1] Liverpool John Moores University,School of Natural Sciences and Psychology
[2] Spanish National Research Council (CSIC),Institute of Food Science, Technology and Nutrition (ICTAN)
[3] Karolinska Institutet,Unit for Preventive Nutrition, Department of Biosciences and Nutrition at Novum
[4] University of Ghent,Department of Public Health, Faculty of Medicine and Health Sciences
[5] Dietary Exposure Assessment Group,International Agency for Research on Cancer
[6] Harokopio University,Department of Nutrition & Dietetics, School of Health Science and Education
[7] Agricultural Research Council Roma,CRA
[8] Technical University of Madrid,NUT, Food and Nutrition Research Center
[9] University of Pécs,ImFine Research Group, Faculty of Physical Activity and Sport Sciences
[10] Ludwig-Maximilians-Universität,Department of Pediatrics
[11] Université de Lille 2,Institute for Medical Information Processing, Biometrics and Epidemiology and German Centre for Vertigo and Balance Disorders
[12] University of Bonn,Hôpital J de Flandre CHRU de Lille, Inserm U995, IFR114, Faculté de Médecine
[13] University of Granada,Department of Nutrition and Food Sciences, Nutritional Physiology
[14] Preventive Medicine and Nutrition Clinic,Department of Medical Physiology, Faculty of Medicine
[15] Private Medical University Salzburg,University of Crete School of Medicine, Department of Social Medicine
[16] University of Zaragoza,Department of Pediatrics
来源：
European Journal of Pediatrics | 2015年 / 174卷
关键词：
Adolescents; Immune cells; Immunophenotyping; Sex; Puberty; Body mass index;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Percentiles 10th, 25th, 50th, 75th and 90th are presented for circulating white blood cells (WBC), neutrophils, lymphocytes, monocytes, eosinophils and basophils in healthy European adolescents (12.5–17.5 years, n = 405, 48.9 % boys), considering age, sex, puberty and body mass index (BMI). CD3+ (mature T cells), CD4+ (T helper), CD8+ (T cytotoxic), CD16+56+ (natural killer), CD19+ (B cells), CD3+CD45RA+, CD4+CD45RA+, CD8+CD45RA+ (naïve), CD3+CD45RO+, CD4+CD45RO+ and CD8+CD45RO+ (memory) lymphocytes were also analysed by immunophenotyping. Girls presented higher WBC, neutrophil, CD3+CD45RO+ and CD4+CD45RO+ cell counts and CD3+/CD19+ ratio, and lower CD3+CD45RA+ and CD4+CD45RA+ counts than boys. Age was associated with higher neutrophil counts and CD3+/CD19+, and lower CD19+ counts; in boys, with lower CD3+CD45RA+, CD4+CD45RA+ and CD8+CD45RA+ counts as well; in girls, with higher WBC, CD3+CD45RO+ and CD4+CD45RO+ counts. Pubertal maturation in boys was associated with lower WBC and lymphocyte counts; in girls, with higher basophil, CD3+CD45RO+ and CD4+CD45RO+ values. BMI was associated with higher WBC counts; in boys, also with higher lymphocyte counts; in girls, with higher neutrophil, CD4+, CD3+CD45RO+ and CD4+CD45RO+ counts.
引用
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页码：999 / 1014
页数：15
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