Effects of NSAIDs on the risk factors of colorectal cancer: A mini review

被引：25

作者：

Hamoya T. ^{[1
,2
]}

Fujii G. ^{[3
]}

Miyamoto S. ^{[1
]}

Takahashi M. ^{[4
]}

Totsuka Y. ^{[3
]}

Wakabayashi K. ^{[5
]}

Toshima J. ^{[2
]}

Mutoh M. ^{[1
,3
]}

机构：

[1] Epidemiology and Prevention Division, Research Center for Cancer Prevention and Screening, National Cancer Center, 5-1-1 Tsukiji, Chuo-ku, Tokyo

[2] Department of Biological Science and Technology, Tokyo University of Science, 6-3-1 Niijuku, Katsusika-ku, Tokyo

[3] Division of Carcinogenesis and Cancer Prevention, National Cancer Center Research Institute, 5-1-1 Tsukiji, Chuo-ku, Tokyo

[4] Central Animal Division, National Cancer Center Research Institute, 5-1-1 Tsukiji, Chuo-ku, Tokyo

[5] Graduate Division of Nutritional and Environmental Sciences, University of Shizuoka, 52-1 Yada, Suruga-ku, Shizuoka

来源：

Genes and Environment | / 38卷 / 1期

基金：

日本学术振兴会;

关键词：

Chemoprevention; Colorectal cancer; Non-steroidal anti-inflammatory drugs; Risk factors;

D O I：

10.1186/s41021-016-0033-0

中图分类号：

学科分类号：

摘要：

Evidence from epidemiological and experimental studies has shown that non-steroidal anti-inflammatory drugs (NSAIDs) reduce the risk of colorectal cancer (CRC). The function of NSAIDs and the molecular targets for chemopreventive effects on CRC have been extensively studied and their data were reported. However, the relation between NSAIDs and the risk factors of CRC have not been fully elucidated yet. Thus, relations between NSAIDs and the risk factors of CRC, such as overweight and obesity, alcohol, aging, hypertriglyceridemia and smoking, are summarized with our data and with recent reported data in this review. © 2016 Hamoya et al.

引用

共 66 条

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