The interplay of histone H2B ubiquitination with budding and fission yeast heterochromatin

被引：0
作者：
Alexis Zukowski
Aaron M. Johnson
机构：
[1] University of Colorado,Department of Biochemistry and Molecular Genetics
[2] Denver - School of Medicine,undefined
来源：
Current Genetics | 2018年 / 64卷
关键词：
SIR complex; Ubp10; Ubiquitination; Silencing; Heterochromatin; Epigenetics;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Mono-ubiquitinated histone H2B (H2B-Ub) is important for chromatin regulation of transcription, chromatin assembly, and also influences heterochromatin. In this review, we discuss the effects of H2B-Ub from nucleosome to higher-order chromatin structure. We then assess what is currently known of the role of H2B-Ub in heterochromatic silencing in budding and fission yeasts (S. cerevisiae and S. pombe), which have distinct silencing mechanisms. In budding yeast, the SIR complex initiates heterochromatin assembly with the aid of a H2B-Ub deubiquitinase, Ubp10. In fission yeast, the RNAi-dependent pathway initiates heterochromatin in the context of low H2B-Ub. We examine how the different silencing machineries overcome the challenge of H2B-Ub chromatin and highlight the importance of using these microorganisms to further our understanding of H2B-Ub in heterochromatic silencing pathways.
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页码：799 / 806
页数：7
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