Assessment of conjugal transfer of antibiotic resistance genes in Salmonella Typhimurium exposed to bile salts

被引：0
作者：
Xinlong He
Juhee Ahn
机构：
[1] Kangwon National University,Department of Medical Biomaterials Engineering
[2] The Third People’s Hospital,Institute of Burn Research
来源：
Journal of Microbiology | 2014年 / 52卷
关键词：
Typhimurium; antibiotic resistance; virulence; gene transfer; bile salt;
D O I：
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中图分类号：
学科分类号：
摘要：
This study was designed to evaluate the transfer potential of antibiotic resistance genes in antibiotic-resistant Salmonella Typhimurium (S. TyphimuriumR) in the presence of bile salts. The resistance of S. TyphimuriumR to ampicillin, kanamycin, and tetracycline was increased by 64-, 64-, and 512-fold, respectively. The highest transfer frequency from S. TyphimuriumR to Escherichia coli was observed at the bile salt concentration of 160 μg/ml (3.8 × 10−3 transferrants/cells). The expression of traJ and traY was suppressed in S. TyphimuriumR by bile salt. This study provides useful information for understanding the conjugative transfer of antibiotic resistance genes in S. Typhimurium under intestinal conditions.
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页码：716 / 719
页数：3
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