Imaging procedures in an intensified high-risk screening program for early detection of hereditary breast cancer: Evaluation by the German Consortium for Breast and Ovarian Cancer

被引：0
作者：
Fallenberg E.M. [1 ]
Schreer I. [2 ]
机构：
[1] Mammadiagnostik, Spezialsprechstunde: „Intensivierte Früherkennung“, Klinik für Radiologie, Charité – Universitätsmedizin Berlin, Berlin
[2] Radiologische Allianz Hamburg-Eimsbüttel, Hamburg
来源：
Der Gynäkologe | 2018年 / 51卷 / 5期
关键词：
Breast neoplasms; male; Breast ultrasonography; Hereditary breast and ovarian cancer syndrome; Magnetic resonance imaging; Mammography;
D O I：
10.1007/s00129-018-4236-2
中图分类号：
学科分类号：
摘要：
According to new data from the Robert Koch Institute, the incidence of new cases of breast cancer is 69,000 per year. Of all affected women, 33% have a risk constellation with a checklist score >2, and 10% of breast cancers are inherited. Due to the fact that tumours in these groups with a proven or calculated high-risk constellation have an earlier onset and more aggressive growth, an intensive early detection program is highly beneficial in terms of earlier detection and successful treatment of these cancers, since prophylactic surgery is only recommended in patients with proven mutations. The early detection program consists of MRI, ultrasound and mammography; mammography screening alone is not sufficient. The exact examination intervals are risk adapted. Due to possible side effects of repeated gadolinium exposition in MRI, a careful risk–benefit calculation has to be provided and adapted in different risk groups. Due to the special behaviour and imaging characteristics of these high-risk tumours, highly experienced radiologists and tight quality control are mandatory. A multidisciplinary team of gynaecologists, psychologists, human geneticists, pathologists and radiologists should manage these patients in specialized centres. © 2018, Springer Medizin Verlag GmbH, ein Teil von Springer Nature.
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页码：380 / 390
页数：10
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