Duodenal gangliocytic paraganglioma, a rare entity among GEP-NET: A case report with immunohistochemical and molecular study

被引：0

作者：

Tatangelo F. ^{[1
]}

Cantile M. ^{[1
]}

Pelella A. ^{[1
]}

Losito N.S. ^{[1
]}

Scognamiglio G. ^{[1
]}

Bianco F. ^{[2
]}

Belli A. ^{[2
]}

Botti G. ^{[1
]}

机构：

[1] Pathology Division, Istituto Nazionale Tumori Fondazione G Pascale -IRCCS, Naples

[2] Division of Surgical Oncology, Istituto Nazionale Tumori Fondazione G Pascale-IRCCS, Naples

来源：

Diagnostic Pathology | / 9卷 / 1期

关键词：

Gangliocytic paraganglioma; ND markers; Neuro D1;

D O I：

10.1186/1746-1596-9-54

中图分类号：

学科分类号：

摘要：

Gastroenteropancreatic neuroendocrine tumors are the most incident neuroendocrine tumors. In the new WHO classification (2010) the embryological derivation of each neoplastic entity is one of the most important parameters. Gangliocytic Paraganglioma is a tumor originating in the hindgut, a rare neoplasm, generally affecting the second portion of the duodenum, the majority of which are benign. Cases of gangliocytic paraganglioma with local metastasis or local recurrence have also been reported.We describe a GP in a 48-year-old caucasian male with an unusual site (4th portion of duodenum) and an interesting immunohistochemical and molecular pattern. In particular, we examined the expression of some neuroendocrine markers and a marker of neuronal differentiation, NeuroD1, whose expression can help to better understand the nature of this neoplasia. © 2014 Tatangelo et al.; licensee BioMed Central Ltd.

引用

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