Non-canonical activation of Notch signaling/target genes in vertebrates

被引：0
作者：
Rajendran Sanalkumar
Sivadasan Bindu Dhanesh
Jackson James
机构：
[1] Rajiv Gandhi Centre for Biotechnology,Neuro
来源：
Cellular and Molecular Life Sciences | 2010年 / 67卷
关键词：
Notch signaling; CBF1-independent Notch; Hes-1; Non-canonical Notch; Neural differentiation; Tumorigenesis;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Evolutionarily conserved Notch signaling orchestrates diverse physiological mechanisms during metazoan development and homeostasis. Classically, ligand-activated Notch receptors transduce the signaling cascade through the interaction of DNA-bound CBF1-co-repressor complex. However, recent reports have demonstrated execution of a CBF1-independent Notch pathway through signaling cross-talks in various cells/tissues. Here, we have tried to congregate the reports that describe the non-canonical/CBF1-independent Notch signaling and target gene activation in vertebrates with specific emphasis on their functional relevance.
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页码：2957 / 2968
页数：11
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